Hematopathology — Flashcards

Flashcard 351: The implicated donors in Transfusion-related acute lung injury are frequently _____.

Answer: multiparous women

Flashcard 352: LAP score is usually _____ in the cells of chronic myeloid leukemia

Answer: low

Flashcard 353: Monosomy 7 is associated with a _____ prognosis in patients with acute myeloid leukemia (AML).

Answer: poor

Flashcard 354: Which RBC membrane skeleton protein is never involved in hereditary spherocytosis?_____

Answer: Glycophorin

Flashcard 355: What is the most specific test for diagnosing hereditary spherocytosis?_____

Answer: eosin-5-maleimide test

Flashcard 356: CD_____ is also known as the leukocyte common antigen.

Answer: 45

Flashcard 357: _____ is an epigenomic regulatory gene mutated in 90% of follicular lymphomas

Answer: MLL2

Flashcard 358: The most common cytogenetic change in multiple myeloma is the deletion of _____

Answer: 13q (or Monosomy 13)

Extra: Deletion of 13q is the most common structural cytogenetic abnormality in Multiple Myeloma, seen in approximately 50% of cases. While translocations involving **14q32** (the IgH locus) are also very common, the most common *deletion* is 13q.

Flashcard 359: What is the earliest hematological response to iron therapy in iron-deficiency anemia?_____

Answer: Bone marrow erythroid hyperplasia

Flashcard 360: t(14;16), del 17p, and t(4;14) in multiple myeloma is associated with a _____ prognosis

Answer: poor