Signal Transduction — Flashcards

Gq proteins _____ the IP3-DAG signaling cascade

PTCH1 is a membrane receptor and a _____ regulator of the Hedgehog signaling pathway.

Hint: positive/negative

In the phospholipase C mechanism of cellular signaling, _____ and diacylglycerol (DAG) activate protein kinase C, which phosphorylates specific proteins to produce physiologic actions

The insulin receptor is a tetramer consisting of two _____ subunits and two beta subunits

Glycogen phosphorylase is regulated by positive feedback by _____ via the alpha receptor (liver and muscle)

Cytokines such as _____ and prolactin hormone also acts by JAK STAT pathway.

TGF- is a growth factor that mediates _____ and angiogenesis. It inhibits inflammation

Elevated levels of hCG (e.g. choriocarcinoma) may cause _____ (males) or hyperthyroidism due to homology between hCG and TSH, FSH, and LH

Which caspase binds to Cyt c and APAF-1 complex?_____

In termination phase of hepatocyte regeneration, hepatocytes return to quiescence with the involvement of antiproliferative factors like _____