Signal Transduction — Flashcards

_____ stimulates fibroblast growth for collagen synthesis

The alpha subunit of G proteins has intrinsic _____ activity and may bind GDP (inactive) or GTP (active)

NF-kB activation pathway: Ubiquitination of IkB results in destruction of _____ and release of the NF-kB transcription factor

Once the mitochondrial membrane has been made permeable, _____ can leak out and activate initiator caspases

Inhibition of Gi via the pertussis toxin results in _____ levels of cAMP

p53 induces apoptosis by activating _____ and BAK, which dimerize and form a pore in the outer mitochondrial membrane

Glucagon, cortisol, and epinephrine induce _____ leading to phosphorylation of serine / threonine residues of the insulin receptor and IRS-1

The Cell Cycle is regulated by Cyclins andCyclin-Dependent Kinases (CDKs) which when _____ allow cells to bypass restriction points (checkpoints)

Vibrio cholerae produces _____ toxin, which ADP-ribosylates and activates Gs resulting in a(n) increase in cAMP in epithelial cells

Gi proteins _____ the cAMP signaling cascade