Nucleic Acid Biochemistry — Flashcards

A _____ is negatively charged DNA wrapped around the outside of positively charged proteins called histones

_____ is found in telomeres with parallel four-stranded DNA and has high guanine content.

The enzyme which adds _____ to 3' ends of chromosomes to avoid loss of genetic material with every duplication is known as Telomerase

Hint: sequence

Recognition and facilitation of excision of _____ occur via enzymes found on two genes: MSH2 (MutS) or MLH1 (MutL)

RNA polymerase _____ makes rRNA

_____ polymerase must see a RNA primer to bind, which is complementary and antiparallel to the polymerase

In response to DNA damage, p53 initially attempts to _____ the cell cycle and facilitates the activity of DNA repair enzymes*bonus-what does it induce that inhibits the cell cycle?

Glutamine-PRPP amidotransferase (purine synthesis) is regulated by negative feedback via _____, IMP, and GMP

UDP is converted to _____ via the enzyme ribonucleotide reductase (pyrimidine synthesis)

Misincorporation of uracil into DNA is seen in the deficiency of _____