A patient with multiple sexual exposures is diagnosed with gonorrhea. What is the appropriate treatment?

Ceftriaxone. ***Ceftriaxone*** - **Ceftriaxone** is the **first-line recommended treatment** for uncomplicated gonorrhea according to **CDC and WHO guidelines**. - Administered as a **single intramuscular injection (500 mg IM)**, it provides highly effective coverage against *Neisseria gonorrhoeae* with minimal resistance. - It works by inhibiting bacterial cell wall synthesis, and is the **gold standard therapy** for gonorrhea treatment. - For patients with multiple sexual exposures, empiric treatment for co-infection with *Chlamydia trachomatis* (doxycycline) should also be considered. *Cefixime* - **Cefixime** was previously used as an oral alternative but is **no longer recommended** as first-line therapy due to **increasing resistance** of *N. gonorrhoeae*. - The CDC removed cefixime from recommended regimens due to **inferior efficacy** compared to ceftriaxone and concerns about treatment failures. - While it is an oral cephalosporin, it is **not appropriate first-line therapy** for gonorrhea. *Doxycycline* - **Doxycycline** is commonly used to treat **co-infection with *Chlamydia trachomatis***, which frequently occurs alongside gonorrhea. - The typical regimen is **100 mg twice daily for 7 days** as adjunctive therapy. - However, doxycycline is **not effective as monotherapy for gonorrhea** and should not be used alone to treat *N. gonorrhoeae* infection. *Acyclovir* - **Acyclovir** is an **antiviral medication** used to treat **herpes simplex virus (HSV)** infections. - It works by inhibiting viral DNA replication and has **no activity against bacterial infections** like gonorrhea. - It would be completely ineffective against *Neisseria gonorrhoeae*. [Practice more Pharmacology PYQs on OnCourse]

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NEET-PG 2024 — Pharmacology

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NEET-PG 2024 Pharmacology PYQs with Answers - Oncourse AI