Biochemistry
4 questionsWhat is the Net Protein Utilization (NPU) for eggs?
What is the limiting amino acid in cereals?
Protein quality assessment is best done by?
Which nutrient is lost maximally in polished rice?
NEET-PG 2015 - Biochemistry NEET-PG Practice Questions and MCQs
Question 751: What is the Net Protein Utilization (NPU) for eggs?
- A. 70
- B. 80
- C. 94 (Correct Answer)
- D. 100
Explanation: ***94*** - **Eggs** are considered a **high-quality protein source** with a Net Protein Utilization (NPU) of approximately **94**, indicating very efficient protein absorption and utilization by the body. - This high NPU reflects the excellent balance of **essential amino acids** in eggs, making them a benchmark for protein quality. *70* - An NPU of 70 is generally considered good but is lower than that of **eggs**, which are among the most efficiently utilized proteins. - This value might be typical for some **plant-based proteins** or mixtures of proteins with slightly less optimal essential amino acid profiles. *80* - An NPU of 80 indicates good protein quality but is still significantly lower than the **NPU of eggs**. - This value is often seen in high-quality **meat proteins** or well-balanced **dairy products**. *100* - An NPU of 100 would mean that all ingested protein is perfectly absorbed and utilized by the body without any loss, which is **theoretically impossible** for biological systems. - While some protein quality metrics might approach 100, **NPU is a measure of actual utilization** and never reaches 100 due to metabolic losses.
Question 752: What is the limiting amino acid in cereals?
- A. Methionine
- B. Tryptophan
- C. Lysine (Correct Answer)
- D. Cysteine
Explanation: ***Lysine*** - **Lysine** is the **first limiting amino acid in cereals** (wheat, rice, corn), meaning it is present in the lowest proportion relative to the body's needs. - This deficiency can impact **protein synthesis** if cereals are the sole or primary protein source without supplementation. - Complementing cereals with **legumes** (rich in lysine but low in methionine) provides complete protein nutrition. *Methionine* - **Methionine** is typically the limiting amino acid in **legumes**, not cereals. - It works with cysteine to provide **sulfur-containing amino acids** essential for various metabolic processes. - This is why cereal-legume combinations (rice and lentils, corn and beans) are nutritionally complementary. *Tryptophan* - **Tryptophan** is an essential amino acid, but it is generally **not the primary limiting amino acid in cereals**. - While corn can be relatively low in tryptophan, **lysine deficiency is more significant** across cereal grains. - It is a precursor to **serotonin** and **niacin**. *Cysteine* - **Cysteine** is a non-essential amino acid, meaning the body can synthesize it from methionine. - While important for protein structure and function, it is **not considered a limiting amino acid** since it can be produced endogenously.
Question 753: Protein quality assessment is best done by?
- A. NPU (Correct Answer)
- B. Biological value
- C. Amino acid score
- D. Digestibility coefficient
Explanation: ***NPU*** - **Net Protein Utilization (NPU)** is considered the best method for assessing protein quality because it measures the percentage of ingested protein that is actually retained and utilized by the body. - It accounts for both the **digestibility** of the protein and the **biological value** of the absorbed amino acids, providing a comprehensive assessment. *Biological value* - **Biological Value (BV)** measures the proportion of absorbed protein from food that becomes incorporated into proteins in the organism's body. - While important, BV does not account for the **digestibility** of the protein, meaning some protein may not be absorbed even if its amino acid profile is excellent. *Digestibility coefficient* - The **digestibility coefficient** measures the proportion of food protein that is absorbed from the gastrointestinal tract. - It only reflects the extent of **absorption** and does not provide information about how efficiently the absorbed amino acids are utilized once inside the body for protein synthesis. *Amino acid score* - The **amino acid score** compares the amino acid profile of a test protein with the amino acid requirements of humans. - This score identifies the **limiting amino acid** but does not factor in the protein's digestibility or how effectively the absorbed amino acids are used by the body.
Question 754: Which nutrient is lost maximally in polished rice?
- A. Proteins
- B. Thiamine (Correct Answer)
- C. Ascorbic acid
- D. Calcitriol
Explanation: ***Thiamine*** - **Polishing rice** removes the outer layers (bran and germ), which are rich in **thiamine (vitamin B1)**. - Significant loss of thiamine can lead to **beriberi**, characterized by neurological and cardiovascular symptoms. *Proteins* - While some protein is lost during milling, the primary nutritional loss in polished rice is not protein. - The germ and aleurone layer contain some protein, but the main carbohydrate-rich endosperm remains. *Ascorbic acid* - **Ascorbic acid (Vitamin C)** is not a significant nutrient in rice, so its loss during polishing is negligible. - Rice is not a primary dietary source of vitamin C. *Calcitriol* - **Calcitriol** is the active form of **vitamin D**, and rice does not naturally contain vitamin D. - Therefore, it cannot be lost during the polishing process.
Community Medicine
5 questionsIn a community of 1,000,000 population, 105 children were born in a year, out of which 5 were stillbirths and 4 died within the first year of life. What is the Infant Mortality Rate (IMR)?
At what fluoride concentration in drinking water does skeletal fluorosis typically occur?
What is the nutritional contribution of the Mid-Day Meal Scheme in terms of pulses?
Vanaspati Ghee is fortified with ?
How often is Village Health and Nutrition Day (VHND) observed?
NEET-PG 2015 - Community Medicine NEET-PG Practice Questions and MCQs
Question 751: In a community of 1,000,000 population, 105 children were born in a year, out of which 5 were stillbirths and 4 died within the first year of life. What is the Infant Mortality Rate (IMR)?
- A. 40 (Correct Answer)
- B. 90
- C. 120
- D. 150
Explanation: ***40*** - **Infant Mortality Rate (IMR)** = (Deaths in first year of life / Live births) × 1,000 - Live births = Total births - Stillbirths = 105 - 5 = **100** - IMR = (4 / 100) × 1,000 = **40 per 1,000 live births** - Stillbirths are excluded from both numerator and denominator as IMR only counts deaths after live birth *90* - This would result from incorrectly using total births (105) instead of live births (100) in the denominator - Wrong calculation: (4 / 105) × 1,000 ≈ 38, not 90 - This option represents a common error but with incorrect arithmetic *120* - This could result from including stillbirths in the numerator: (5+4) / 100 × 1,000 = 90, not 120 - Or from other miscalculations mixing up the numerator and denominator - Does not follow the standard IMR formula *150* - This represents a significant calculation error - May result from using wrong base (per 100 instead of per 1,000) or including stillbirths incorrectly - Such high IMR does not match the given data of 4 infant deaths per 100 live births
Question 752: At what fluoride concentration in drinking water does skeletal fluorosis typically occur?
- A. < 1.5 mg/L
- B. 1.5-3 mg/L
- C. 3-6 mg/L (Correct Answer)
- D. > 10 mg/L
Explanation: ***3-6 mg/L*** - Chronic exposure to drinking water with **fluoride concentrations of 3-6 mg/L** represents the **threshold range** where **early skeletal fluorosis** begins to manifest. - At concentrations **≥4 mg/L**, fluoride accumulation in bones exceeds the body's excretory capacity, leading to **increased bone density, osteosclerosis**, and early symptoms like **joint stiffness and bone pain**. - This range captures the **onset of skeletal manifestations**, though more severe changes occur at higher concentrations. *< 1.5 mg/L* - This range is **optimal for preventing dental caries** without causing adverse effects. - Fluoride concentrations below 1.5 mg/L are **safe** and do not cause skeletal or dental fluorosis. - Many water fluoridation programs target **0.5-1.0 mg/L** for dental health benefits. *1.5-3 mg/L* - This range primarily causes **dental fluorosis** (enamel mottling and discoloration) with chronic exposure, especially during tooth development. - **Skeletal fluorosis does not typically occur** at these concentrations, as the threshold for bone involvement is higher. - This is considered the range for cosmetic concerns rather than systemic skeletal disease. *> 10 mg/L* - Concentrations exceeding 10 mg/L lead to **severe, crippling skeletal fluorosis** with marked bone deformities, ligament calcification, and potential neurological complications. - This represents **advanced disease** rather than the typical onset of skeletal fluorosis. - Such high concentrations are found in endemic fluorosis regions with contaminated groundwater.
Question 753: What is the nutritional contribution of the Mid-Day Meal Scheme in terms of pulses?
- A. Provides 30% of daily protein needs
- B. Provides 30 gm of pulses per day (Correct Answer)
- C. Provides 50% of daily energy needs
- D. None of the options
Explanation: ***Provides 30 gm of pulses per day*** - The Mid-Day Meal Scheme specifies the provision of **30 grams of pulses** daily for **upper primary classes (VI-VIII)**, and 20 grams for primary classes (I-V), contributing to protein intake. - This quantity ensures a consistent supply of **plant-based protein** as part of a balanced diet for schoolchildren. - The question refers to the commonly cited **30g standard for upper primary**, which is the most frequently referenced figure in examinations. *Provides 30% of daily protein needs* - While pulses contribute to protein intake, specifying a fixed **30% of daily protein needs** is not a direct nutritional guideline of the scheme for pulses alone. - The scheme focuses on providing a certain **quantity of pulses in grams**, from which the protein contribution is derived. *Provides 50% of daily energy needs* - The Mid-Day Meal Scheme aims to provide **300 kcal for primary** and **700 kcal for upper primary classes**, but this is derived from the entire meal composition (cereals, pulses, vegetables), not just pulses. - The scheme's **energy contribution** is holistic and represents approximately 33% of daily energy requirements, not 50%. *None of the options* - One of the provided options accurately reflects a specific guideline of the Mid-Day Meal Scheme regarding pulses. - The scheme has clear stipulations for the **quantity of pulses in grams** to be served.
Question 754: Vanaspati Ghee is fortified with ?
- A. Iodine
- B. Vitamin A (Correct Answer)
- C. Iron
- D. Calcium
Explanation: ***Vitamin A*** - **Vanaspati Ghee** is commonly fortified with **Vitamin A** to improve its nutritional value and address deficiencies. - Fortification helps to combat **Vitamin A deficiency disorders**, such as **night blindness**. *Iodine* - **Iodine** is typically used to fortify **table salt** to prevent **goiter** and **iodine deficiency disorders**. - It is not commonly added to Vanaspati Ghee. *Iron* - **Iron** is commonly used to fortify foods like **flour** and **cereals** to combat **anemia**. - Vanaspati Ghee is not a common vehicle for iron fortification. *Calcium* - **Calcium** is often added to dairy products or certain beverages to support **bone health**. - It is not a standard fortification for Vanaspati Ghee.
Question 755: How often is Village Health and Nutrition Day (VHND) observed?
- A. Every 6 months
- B. Every week
- C. Every year
- D. Once a month (Correct Answer)
Explanation: ***Once a month*** - Village Health and Nutrition Day (VHND) is typically observed on a **fixed day each month** to provide essential health and nutrition services at the community level. - This regular schedule ensures consistent access to services like **immunization**, **antenatal care**, and **health education** for rural populations. *Every week* - Observing VHND every week would be a **logistical challenge** given the resources and personnel required for comprehensive service delivery. - Most community-level health programs are not designed for weekly, full-scale events due to the **intensive resource allocation** involved. *Every 6 months* - A frequency of every six months would be **insufficient** to address the ongoing health and nutrition needs of the community, especially for routine immunizations and growth monitoring. - Many public health interventions require more frequent contact to be effective in **preventing disease** and **promoting health**. *Every year* - An annual observation of VHND would be **highly inadequate** for managing public health programs, as it would miss critical windows for interventions like timely immunizations and growth assessments for infants and children. - Annual events are generally reserved for specific campaigns or assessments, not for broad, routine health service delivery.
Pharmacology
1 questionsWhat is the recommended therapeutic supplementation of iron and folic acid for adults with deficiency?
NEET-PG 2015 - Pharmacology NEET-PG Practice Questions and MCQs
Question 751: What is the recommended therapeutic supplementation of iron and folic acid for adults with deficiency?
- A. 20 mg iron, 500 mcg folic acid
- B. 40 mg iron, 250 mcg folic acid
- C. 100 mg iron, 500 mcg folic acid (Correct Answer)
- D. 100 mg iron, 100 mcg folic acid
Explanation: ***100 mg iron, 500 mcg folic acid*** - For adults with **iron deficiency anemia**, the therapeutic dose of elemental iron is typically **100-200 mg daily**, commonly given as ferrous sulfate 325 mg (containing ~65 mg elemental iron) 2-3 times daily. **100 mg is an appropriate therapeutic dose**. - For **folic acid deficiency**, the standard therapeutic dose is **1-5 mg (1000-5000 mcg) daily** for treating established deficiency. However, **500 mcg (0.5 mg)** represents a minimal therapeutic/high prophylactic dose that may be used in milder deficiencies or as initial supplementation. Among the given options, this is the most appropriate combination. *20 mg iron, 500 mcg folic acid* - **20 mg of iron** is grossly insufficient for therapeutic supplementation in iron deficiency anemia and would fail to correct the anemia adequately. - While 500 mcg folic acid has some therapeutic value, the **iron dose is far too low** for treatment. *40 mg iron, 250 mcg folic acid* - **40 mg of iron** is a prophylactic dose (used in pregnancy or prevention) but is **insufficient for therapeutic correction** of established iron deficiency anemia. - **250 mcg of folic acid** is also a prophylactic dose and inadequate for treating established deficiency. *100 mg iron, 100 mcg folic acid* - **100 mg of iron** is an appropriate therapeutic dose for treating **iron deficiency anemia**. - However, **100 mcg of folic acid** is purely a maintenance/prophylactic dose found in multivitamins and is **grossly insufficient** for treating established folic acid deficiency.