Internal Medicine
1 questionsA 50 year old male presents with fever and malaise for 4 months and pain in the knees and ankles. Blood tests are normal apart from a raised ESR. Chest x-ray shows bilateral hilar adenopathy and pulmonary infiltrates most severe in the upper and mid zones. Mantoux test is negative. What is the most likely diagnosis?
NEET-PG 2015 - Internal Medicine NEET-PG Practice Questions and MCQs
Question 1281: A 50 year old male presents with fever and malaise for 4 months and pain in the knees and ankles. Blood tests are normal apart from a raised ESR. Chest x-ray shows bilateral hilar adenopathy and pulmonary infiltrates most severe in the upper and mid zones. Mantoux test is negative. What is the most likely diagnosis?
- A. Tuberculosis
- B. Sarcoidosis (Correct Answer)
- C. Asbestosis
- D. Berylliosis
Explanation: ***Sarcoidosis*** - The constellation of **bilateral hilar adenopathy**, pulmonary infiltrates (especially in upper/mid zones), **arthralgia** (knees and ankles), and a **negative Mantoux test** in a patient with unexplained fever and malaise is highly suggestive of sarcoidosis [1]. - A **raised ESR** is a non-specific inflammatory marker often seen in sarcoidosis. *Tuberculosis* - While tuberculosis can cause fever, malaise, pulmonary infiltrates, and elevated ESR, a **negative Mantoux test** makes primary or active tuberculosis less likely in an immunocompetent individual. - **Bilateral hilar adenopathy** is also less typical of primary pulmonary tuberculosis compared to sarcoidosis. *Asbestosis* - This is an **occupational lung disease** caused by asbestos exposure, primarily presenting with **progressive dyspnea** and **restrictive lung disease**. - It characteristically involves the **lower lobes**, causes **pleural plaques**, and is not typically associated with acute arthralgia, fever, or prominent hilar adenopathy. *Berylliosis* - This is another **occupational lung disease** resulting from beryllium exposure, often mimicking sarcoidosis both clinically and pathologically [2]. - However, without a history of **beryllium exposure** and given the classic presentation, sarcoidosis is a more prevalent default diagnosis [2].
Orthopaedics
6 questionsThe Salter Harris classification is used for classifying which type of injuries?
In which condition is the Milwaukee Brace primarily used?
Vertebra Plana is associated with all of the following conditions except -
Lift off test is done to assess the function of:
The anterior humeral line and radiocapitellar alignment are most commonly disturbed in -
In which condition is the Hamilton Ruler test sign positive?
NEET-PG 2015 - Orthopaedics NEET-PG Practice Questions and MCQs
Question 1281: The Salter Harris classification is used for classifying which type of injuries?
- A. Soft tissue injuries in pediatric patients
- B. Long bone fractures without growth plate involvement
- C. Joint dislocations in pediatric orthopedics
- D. Fractures involving the physis in children (Correct Answer)
Explanation: ***Fractures involving the physis in children*** - The **Salter-Harris classification system** is specifically designed for classifying fractures that involve the **growth plate (physis)** in children. - This system helps predict the risk of **growth disturbance** and guides treatment decisions based on the fracture pattern. *Soft tissue injuries in pediatric patients* - The Salter-Harris classification does not apply to **soft tissue injuries** like sprains or strains. - Soft tissue injuries are assessed using different classification systems or descriptive terms. *Long bone fractures without growth plate involvement* - Fractures in children that do not involve the growth plate are classified using descriptive terms, such as **transverse**, **oblique**, or **spiral fractures**, or other systems like the **AO pediatric classification**, not Salter-Harris. - The Salter-Harris system is unique to physis involvement. *Joint dislocations in pediatric orthopedics* - **Joint dislocations** involve the displacement of bones at a joint and are classified by the direction of displacement (e.g., anterior, posterior). - They do not involve a fracture of the growth plate itself, so the Salter-Harris system is not applicable.
Question 1282: In which condition is the Milwaukee Brace primarily used?
- A. Spondylolisthesis
- B. Scheuermann's Disease
- C. Congenital Kyphosis
- D. Adolescent Idiopathic Scoliosis (Correct Answer)
Explanation: ***Adolescent Idiopathic Scoliosis*** - The **Milwaukee Brace** is a widely recognized and historically significant orthotic device used primarily for the non-surgical management of **scoliosis**, particularly **adolescent idiopathic scoliosis**. - It works by applying corrective forces to the spine to prevent further curvature progression and often allows for some correction during growth. *Congenital Kyphosis* - **Congenital kyphosis** is a spinal deformity present at birth, often caused by vertebral malformations, which is typically managed surgically, especially if progressive. - While bracing can be attempted for mild, flexible curves, the Milwaukee Brace is not the primary or most effective treatment for its structural nature. *Scheuermann's Disease* - **Scheuermann's disease** is a form of kyphosis where wedging of the vertebrae causes a rigid, exaggerated forward curvature of the thoracic spine. - While bracing can be used to treat Scheuermann's disease, the **Milwaukee brace** is not the brace of choice. A **kyphosis-specific brace** such as a kyphosis-bifocal brace or a molded thoracolumbar sacral orthosis (TLSO) is typically preferred. *Spondylolisthesis* - **Spondylolisthesis** involves the forward slippage of one vertebra over another, often in the lumbar spine. - Management typically involves activity restriction, physical therapy, and sometimes surgical fusion, with bracing aimed at stabilizing the spine rather than correcting a lateral curve, making the Milwaukee Brace unsuitable.
Question 1283: Vertebra Plana is associated with all of the following conditions except -
- A. Leukemia
- B. Excessive use of systemic steroids
- C. Scheurmanns Disease (Correct Answer)
- D. Histiocytosis X
Explanation: ***Scheurmanns Disease*** - **Scheuermann's disease** is characterized by **vertebral wedging** and **kyphosis**, not a complete flattening of the vertebral body (vertebra plana). - It involves irregularities of the vertebral endplates and Schmorl's nodes, differing from the destructive process seen in vertebra plana. *Histiocytosis X* - **Histiocytosis X** (Langerhans cell histiocytosis) can cause destructive lesions in the vertebral body, leading to its collapse and the appearance of **vertebra plana**. - This condition is common among young children and is associated with eosinophilic granuloma. *Leukemia* - **Leukemic infiltration** of bone marrow can weaken vertebral bodies, causing **osteopenia** and eventual collapse, which may present as vertebra plana. - This is often seen in pediatric patients with acute lymphoblastic leukemia. *Excessive use of systemic steroids* - Long-term or excessive use of **systemic corticosteroids** can lead to **osteoporosis**, which weakens bones and makes vertebral bodies prone to compression fractures and collapse into vertebra plana. - This iatrogenic cause results from the negative impact of steroids on bone formation and increased bone resorption.
Question 1284: Lift off test is done to assess the function of:
- A. Supraspinatus muscle function
- B. Infraspinatus muscle function
- C. Subscapularis muscle function (Correct Answer)
- D. Teres Minor muscle function
Explanation: ***Subscapularis muscle function*** - The **Lift-off test**, or Gerber's Lift-off test, specifically assesses the integrity and strength of the **subscapularis muscle** by evaluating its internal rotation and extension strength. - A positive test occurs when the patient is unable to lift their hand off their back, indicating a **subscapularis tear or weakness**. *Supraspinatus muscle function* - The **supraspinatus muscle** is primarily tested with the **empty can test** or full can test, which assess its role in shoulder abduction. - These tests evaluate for **impingement** or **tears** of the supraspinatus tendon. *Infraspinatus muscle function* - The **infraspinatus muscle** is mainly responsible for external rotation and is assessed using tests like the **resisted external rotation test** with the arm at the side. - This test is used to detect **infraspinatus tears** or weakness. *Teres Minor muscle function* - The **teres minor muscle** also contributes to external rotation of the shoulder, often tested in conjunction with the infraspinatus. - Its function can be isolated by testing resisted **external rotation** in 90 degrees of abduction and external rotation.
Question 1285: The anterior humeral line and radiocapitellar alignment are most commonly disturbed in -
- A. Supracondylar Fracture of the humerus (Correct Answer)
- B. Monteggia Fracture dislocation
- C. Fracture of Proximal Radius
- D. Fracture lateral condyle of the humerus
Explanation: ***Supracondylar Fracture of the humerus*** - **Anterior humeral line** passes through the **anterior cortex of the humerus** and should intersect the middle third of the capitellum in a normal elbow. - In supracondylar fractures, particularly those with **posterior displacement**, this line is often displaced **anteriorly or posteriorly**, failing to intersect the capitellum correctly. Additionally, the **radiocapitellar alignment** refers to the relationship between the **radius head** and the **capitellum**. Fractures and displacements around the elbow joint, such as supracondylar fractures, can disrupt this alignment. *Fracture lateral condyle of the humerus* - While a fracture of the lateral condyle can affect the elbow joint, it primarily involves a part of the **articular surface** and not necessarily the overall alignment of the entire distal humerus relative to the capitellum in the same way a supracondylar fracture does. - The **lateral condyle** is a smaller segment, and its fracture may not significantly alter the anterior humeral line **unless there is significant displacement** that indirectly affects the alignment of the capitellum. *Monteggia Fracture dislocation* - A **Monteggia fracture** involves a fracture of the **ulna** with dislocation of the **radial head** at the elbow. - While radiocapitellar alignment is severely disrupted, the **anterior humeral line** itself, which assesses the distal humerus, is typically **unaffected** as the primary injury is in the forearm bones and the radial head. *Fracture of Proximal Radius* - A fracture of the proximal radius (e.g., **radial head or neck fracture**) primarily affects the **radial articular surface** and its alignment with the capitellum. - While **radiocapitellar alignment** would clearly be disturbed, the position of the **distal humerus** relative to the capitellum, which the anterior humeral line evaluates, usually remains intact.
Question 1286: In which condition is the Hamilton Ruler test sign positive?
- A. Anterior dislocation of shoulder (Correct Answer)
- B. Posterior dislocation of shoulder
- C. Luxatio erecta
- D. Acromioclavicular joint dislocation
Explanation: ***Anterior dislocation of shoulder*** - The **Hamilton Ruler test** is positive when a straight edge, like a ruler, can be laid across the **lateral aspect of the deltoid prominence** from the acromion to the lateral epicondyle. - This is indicative of the **loss of the normal rounded contour of the shoulder**, which occurs due to the humeral head dislocating anteriorly. *Acromioclavicular joint dislocation* - This condition presents with a **"step-off" deformity** at the AC joint and pain directly over the joint, but the overall contour of the shoulder glenohumeral joint is preserved. - The deltoid prominence remains intact, making the Hamilton Ruler test negative. *Posterior dislocation of shoulder* - In posterior dislocation, the **humeral head moves posteriorly**, and the anterior contour of the shoulder might appear flattened, but the characteristic prominent anterior bulge seen in anterior dislocation is absent. - The Hamilton Ruler test specifically assesses for the loss of the lateral deltoid prominence, which is more typical of anterior displacement. *Luxatio erecta* - **Luxatio erecta** is an inferior dislocation of the shoulder where the arm is fixed in an **abducted and externally rotated position**, making it appear "erect". - While a severe type of shoulder dislocation, the specific anatomical changes that lead to a positive Hamilton Ruler test (loss of lateral deltoid prominence with the humeral head moving anteriorly and medially) are not typically present in this configuration.
Pharmacology
2 questionsWhich of the following drugs is an alpha 2 agonist?
Which of the following is the only clinically available depolarizing muscle relaxant?
NEET-PG 2015 - Pharmacology NEET-PG Practice Questions and MCQs
Question 1281: Which of the following drugs is an alpha 2 agonist?
- A. Apraclonidine (Correct Answer)
- B. Timolol
- C. PG analogues
- D. Verapamil
Explanation: ***Apraclonidine*** - **Apraclonidine** is a synthetic **alpha-2 adrenergic agonist** that reduces aqueous humor production and increases uveoscleral outflow, thereby lowering intraocular pressure. - It is primarily used for the short-term treatment of **open-angle glaucoma** or ocular hypertension. *Timolol* - **Timolol** is a **non-selective beta-adrenergic blocker** that reduces aqueous humor production, leading to a decrease in intraocular pressure. - It does not act on alpha-2 receptors, distinguishing it from apraclonidine. *PG analogues* - **Prostaglandin analogues** (PG analogues) such as latanoprost, bimatoprost, and travoprost are primarily used to treat glaucoma by **increasing uveoscleral outflow** of aqueous humor. - They act on **prostaglandin F2α receptors**, not alpha-2 adrenergic receptors. *Verapamil* - **Verapamil** is a **calcium channel blocker** primarily used to treat hypertension, angina, and arrhythmias. - It acts by blocking calcium channels in vascular smooth muscle and the heart, and does not have significant alpha-2 adrenergic agonist activity.
Question 1282: Which of the following is the only clinically available depolarizing muscle relaxant?
- A. Decamethonium
- B. Suxamethonium (Correct Answer)
- C. Mivacurium
- D. None of the options
Explanation: ***Suxamethonium*** - **Suxamethonium** (also known as succinylcholine) is currently the **only depolarizing neuromuscular blocker** available for clinical use. - It works by mimicking acetylcholine, binding to and activating nicotinic acetylcholine receptors at the **neuromuscular junction**, causing initial muscle fasciculations followed by relaxation. *Decamethonium* - **Decamethonium** is a depolarizing neuromuscular blocker but is **no longer clinically available** due to its prolonged action and side effects. - It also acts by opening nicotinic acetylcholine receptor channels, leading to depolarization and muscle paralysis. *Mivacurium* - **Mivacurium** is a **nondepolarizing neuromuscular blocker**, meaning it acts as a competitive antagonist at the acetylcholine receptor. - It is known for its **short duration of action** due to rapid hydrolysis by plasma cholinesterases but is not depolarizing. *None of the options* - This option is incorrect because suxamethonium is indeed a clinically available depolarizing muscle relaxant. - The question specifically asks for the *only* clinically available one, which suxamethonium fulfills.
Radiology
1 questionsEpidural hematoma on CT scan shows which of the following?
NEET-PG 2015 - Radiology NEET-PG Practice Questions and MCQs
Question 1281: Epidural hematoma on CT scan shows which of the following?
- A. Biconvex hyperdense lesion (Correct Answer)
- B. Crescent-shaped hyperdense lesion
- C. Biconcave hypodense lesion
- D. Ring-enhancing hypodense lesion
Explanation: ***Biconvex hyperdense lesion*** - An epidural hematoma is characterized by a **biconvex** (lens-shaped) collection of blood between the dura mater and the skull. - Since it is an acute hemorrhage, the blood appears **hyperdense** (bright white) on a CT scan. *Crescent-shaped hyperdense lesion* - A **crescent shape** is characteristic of an **acute subdural hematoma**, not an epidural hematoma. - While acute subdural hematomas are also hyperdense, their crescent shape (following the contour of the brain) distinguishes them from the biconvex epidural hematomas. - Epidural hematomas are limited by suture lines and appear lens-shaped, while subdural hematomas can cross suture lines. *Biconcave hypodense lesion* - A **biconcave** shape is not a standard description in neuroradiology and does not represent epidural hematoma. - **Hypodense** would indicate an older lesion or other pathology, not acute hemorrhage. *Ring-enhancing hypodense lesion* - **Ring-enhancing lesions** are typically associated with abscesses, glioblastoma, or metastatic tumors, not an acute hematoma. - A **hypodense** (darker) center with enhancement would indicate an abscess or necrotic tumor, not a fresh extravasation of blood.