NEET-PG 2015 Practice Questions

Q: At the end of anaesthesia after discontinuation of nitrous oxide and removal of endotracheal tube, 100% oxygen is administered to the patient to prevent:

Diffusion Hypoxia. ***Diffusion Hypoxia*** - Post-anaesthesia administration of 100% oxygen prevents **diffusion hypoxia**, a phenomenon where **nitrous oxide** rapidly diffuses out of the blood into the alveoli, diluting alveolar oxygen and carbon dioxide. - This rapid outflow of nitrous oxide can lead to a significant drop in **partial pressure of oxygen** in the alveoli, causing hypoxemia if not counteracted with high inspired oxygen. *Second gas effect* - The **second gas effect** refers to the phenomenon where the rapid uptake of a highly soluble anesthetic (like nitrous oxide) accelerates the uptake of a co-administered less soluble anesthetic. - This is an effect related to the **induction phase** of anesthesia, not emergence, and is distinct from the issues arising from nitrous oxide washout. *Bronchospasm* - **Bronchospasm** is an acute constriction of the bronchioles, often triggered by irritants, allergens, or certain medications. - While it can occur during emergence from anesthesia, it is not directly prevented by administering 100% oxygen and is typically managed with bronchodilators. *Hyperoxia* - **Hyperoxia** is a condition of excess oxygen in the body, which can be detrimental, but it is not the primary concern immediately following the discontinuation of nitrous oxide. - Administering 100% oxygen in this context is a **controlled, short-term measure** to prevent a more immediate and severe issue (hypoxia) rather than causing chronic hyperoxia.

Q: All of the following are features of Zollinger Ellison syndrome except:

Beta cell tumours of the pancreas. ***Beta cell tumours of the pancreas*** - Zollinger-Ellison syndrome (ZES) is caused by **gastrinomas**, which are **neuroendocrine tumors** that typically arise from the **gastrin-producing G cells**, not the insulin-producing beta cells, of the pancreas or duodenum. - While pancreatic tumors are common in ZES, they are specifically **gastrinomas**, leading to excessive gastrin secretion. *Severe diarrhoea* - This is a common feature of ZES resulting from the **high acid output** reaching the small intestine. - The excessive acid inactivates pancreatic lipase, leading to **maldigestion** and stimulates fluid and electrolyte secretion, causing secretory diarrhea. *Very high acid output* - ZES is characterized by the **overproduction of gastrin**, which stimulates the parietal cells of the stomach to secrete large amounts of **hydrochloric acid**. - This leads to a significantly **increased basal and maximal acid output** in the stomach. *Intractable peptic ulcers* - The extremely high gastric acid secretion in ZES causes **multiple, recurrent, and often refractory peptic ulcers**, which can be located in atypical sites such as the jejunum. - These ulcers are typically difficult to treat with standard anti-ulcer medications due to the persistent gastric hypersecretion.

Q: What is the main contraindication for performing a liver biopsy?

Severe coagulopathy. ***Severe coagulopathy*** - **Severe coagulopathy** is the main contraindication for liver biopsy due to a significantly increased risk of **hemorrhage** [1]. - A **prothrombin time (PT)** or **activated partial thromboplastin time (aPTT)** significantly prolonged beyond the normal range, or an **INR > 1.5**, should be corrected before the procedure [1]. *Severe thrombocytopenia* - While **thrombocytopenia** (platelet count <50,000/µL) does increase bleeding risk, it is often correctable with a **platelet transfusion** prior to biopsy, making it a relative rather than an absolute contraindication [1]. - The risk of major bleeding is typically lower with isolated thrombocytopenia compared to severe coagulopathy. *Liver hemangioma* - The presence of a **liver hemangioma** at the biopsy site is a contraindication as biopsying it can lead to massive hemorrhage. - However, if the biopsy can be performed safely away from the hemangioma, it is not an absolute contraindication to the procedure itself. *Presence of ascites* - **Ascites** can complicate a liver biopsy by increasing the risk of **peritoneal bleeding** and difficulty in targeting the liver [1]. - However, it is often manageable by draining the ascites or using imaging guidance, making it a relative contraindication rather than an absolute one [1].

Q: Which of the following is true about Mallory-Weiss tear -

It is a mucosal tear not extending through the muscle layer. ***It is a mucosal tear not extending through the muscle layer*** - A **Mallory-Weiss tear** is defined as a longitudinal tear in the **mucosa** of the distal esophagus or proximal stomach. - These tears typically do not extend through the **muscularis propria** layer, distinguishing them from a Boerhaave syndrome, which is a full-thickness rupture. *It is more common in women than men* - Mallory-Weiss tears show a **male predominance** with a male-to-female ratio of approximately 2-4:1. - Risk factors like **alcohol use disorder** and forceful vomiting are more common in males, contributing to this gender distribution. *It is common in young individuals* - Mallory-Weiss tears are more common in **middle-aged to older individuals**, typically between 40 and 60 years old. - The condition is rare in young children or teenagers. *It is associated with achalasia cardia* - While both conditions affect the esophagus, there is **no direct causal association** between Mallory-Weiss tears and **achalasia cardia**. - Achalasia is a motility disorder, whereas Mallory-Weiss tears are caused by sudden increases in intra-abdominal pressure.

Q: Which of the following statements is true regarding a Monteggia fracture?

Upper ulnar fracture with dislocated radial head.. ***Upper ulnar fracture with dislocated radial head.*** - A Monteggia fracture is classically defined as a fracture of the **proximal or middle third of the ulna** accompanied by an **anterior dislocation of the radial head**. - This injury pattern disrupts the alignment of the **forearm bones** and the **elbow joint**, requiring careful reduction and stabilization. *Upper radial fracture with dislocated ulna.* - This statement incorrectly identifies the fractured bone as the radius and the dislocated bone as the ulna. - The defining characteristic of a Monteggia fracture is the **ulnar fracture** and **radial head dislocation**. *Lower radial fracture with dislocated ulna.* - This describes a different type of injury, such as a **Galeazzi fracture**, which involves a **radial shaft fracture** with dislocation of the **distal radioulnar joint**. - It does not fit the criteria for a Monteggia fracture pattern. *Lower ulnar fracture with dislocated radius.* - This description is not consistent with a Monteggia fracture, which specifically involves the **proximal ulna** and **radial head dislocation**. - A lower ulnar fracture with distal radius dislocation is a distinct injury pattern.

Q: At what rate should dopamine be administered for inotropic support in a severely dehydrated child?

1-5 microgram/kg/min. ***1-5 microgram/kg/min*** - This dosage range of **dopamine** primarily targets **beta-1 adrenergic receptors**, leading to **increased myocardial contractility** (inotropic effect) and improved cardiac output. - It is appropriate for managing **hypotension** and poor perfusion in a severely dehydrated child after initial **fluid resuscitation** has been attempted but was insufficient. *0.1-0.5 microgram/kg/min* - This very low dose range of dopamine primarily stimulates **dopaminergic receptors** in the renal and mesenteric vascular beds. - Its main effect is **vasodilation** in these areas, which increases blood flow to the kidneys and gut, but it provides minimal to no **inotropic support**. *1-5 mg/kg/min* - This dosage is significantly too high, as it is in milligrams rather than micrograms. - Administering dopamine at this rate would lead to severe **toxicity**, including profound **tachycardia**, ventricular arrhythmias, and extreme **vasoconstriction**. *10-15 mg/kg/min* - This dopamine dosage is also excessively high, again due to being in milligrams per minute rather than micrograms per minute. - Such a dose would be **lethal**, causing catastrophic cardiovascular collapse due to overwhelming **alpha-adrenergic stimulation** and severe arrhythmias.

Q: Where does spontaneous esophageal rupture (Boerhaave syndrome) most commonly occur?

Above the diaphragmatic aperture. ***Above the diaphragmatic aperture*** - Boerhaave syndrome, or spontaneous esophageal rupture, most commonly occurs in the **distal esophagus**, just above the diaphragmatic aperture. - This region is particularly susceptible due to increased **intraluminal pressure** during forceful vomiting, combined with a lack of muscular support and a thinner esophageal wall. - The rupture typically occurs in the **left posterolateral wall** of the lower third of the esophagus, approximately **2-5 cm above the gastroesophageal junction**. *Below the diaphragmatic aperture* - Ruptures below the diaphragmatic aperture are less common in Boerhaave syndrome, as the **lower esophageal sphincter** and surrounding diaphragmatic crura provide more support. - While other forms of esophageal injury can occur here, a spontaneous rupture due to vomiting is less typical in this location. *Pharyngoesophageal junction* - Ruptures at the pharyngoesophageal junction are known as **Zenker's diverticulum ruptures** or other types of perforation, typically not Boerhaave syndrome. - This area is prone to tears from instrumentation or foreign bodies but not usually from the extreme pressure of forceful vomiting (which affects the distal esophagus more). *At the crossing of the arch of aorta* - The mid-esophagus at the level of the aortic arch is not a common site for Boerhaave syndrome. - Although the esophagus is constricted here, the primary stress during forceful vomiting is concentrated in the **distal esophagus**.

Q: ESWL is contraindicated in which of the following stones -

Cystine stones. ***Cysteine stones*** - **Cystine stones** are very dense and hard, making them resistant to fragmentation by the shock waves generated during **Extracorporeal Shock Wave Lithotripsy (ESWL)**. - Due to their resistance to fragmentation, ESWL is generally ineffective for cystine stones, and other treatments like **ureteroscopy** or **percutaneous nephrolithotomy (PCNL)** are often preferred. *Oxalate Stones* - **Calcium oxalate stones** are generally **amenable to ESWL** as they are effectively fragmented by shock waves. - They are the **most common type of kidney stone** and often respond well to lithotripsy. *Urate stones* - **Uric acid stones** are typically **radiolucent** but are often **well-fragmented by ESWL**. - Their non-calcium composition does not hinder the effectiveness of shock waves. *Phosphate stones* - **Struvite (magnesium ammonium phosphate) stones** and **calcium phosphate stones** generally respond well to ESWL. - While sometimes large and branched (**staghorn calculi**), the individual components are susceptible to shock wave fragmentation, though multiple sessions or adjunctive therapies might be needed.

Question 1

At the end of anaesthesia after discontinuation of nitrous oxide and removal of endotracheal tube, 100% oxygen is administered to the patient to prevent:

Accepted Answer

Diffusion Hypoxia

Answer

Second gas effect

Answer

Bronchospasm

Answer

Hyperoxia

Question 2

All of the following are features of Zollinger Ellison syndrome except:

Accepted Answer

Beta cell tumours of the pancreas

Answer

Severe diarrhoea

Answer

Very high acid output

Answer

Intractable peptic ulcers

Question 3

What is the main contraindication for performing a liver biopsy?

Accepted Answer

Severe coagulopathy

Answer

Severe thrombocytopenia

Answer

Liver hemangioma

Answer

Presence of ascites

Question 4

Which of the following is true about Mallory-Weiss tear -

Accepted Answer

It is a mucosal tear not extending through the muscle layer

Answer

It is more common in women than men

Answer

It is common in young individuals

Answer

It is associated with achalasia cardia

Question 5

Which of the following statements about nabothian cysts is true?

Accepted Answer

Squamous epithelium grows over columnar epithelium, blocking mucus-secreting glands.

Answer

It is a premalignant condition that requires excision.

Answer

It is a malignant condition.

Answer

It may be associated with chronic irritation and inflammation but is not defined by it.

Question 6

Which of the following statements is true regarding a Monteggia fracture?

Accepted Answer

Upper ulnar fracture with dislocated radial head.

Answer

Upper radial fracture with dislocated ulna.

Answer

Lower radial fracture with dislocated ulna.

Answer

Lower ulnar fracture with dislocated radius.

Question 7

Which of the following is NOT a recognized cause of Urothelial Carcinomas?

Accepted Answer

Alcohol consumption

Answer

Industrial solvents

Answer

Exposure to thorotrast

Answer

Smoking

Question 8

At what rate should dopamine be administered for inotropic support in a severely dehydrated child?

Accepted Answer

1-5 microgram/kg/min

Answer

0.1-0.5 microgram/kg/min

Answer

1-5 mg/kg/min

Answer

10-15 mg/kg/min

Question 9

Where does spontaneous esophageal rupture (Boerhaave syndrome) most commonly occur?

Accepted Answer

Above the diaphragmatic aperture

Answer

Below the diaphragmatic aperture

Answer

Pharyngoesophageal junction

Answer

At the crossing of the arch of aorta

Question 10

ESWL is contraindicated in which of the following stones -

Accepted Answer

Cystine stones

Answer

Urate stones

Answer

Phosphate stones

Answer

Oxalate Stones

NEET-PG 2015

Anesthesiology

Internal Medicine

Obstetrics and Gynecology

Orthopaedics

Pathology

Pediatrics

Surgery