NEET-PG 2013 Practice Questions

Q: What is the primary clinical use of Sugammadex in anesthesia?

Reversal of NM blockers. ***Reversal of NM blockers*** - **Sugammadex** is a modified gamma-cyclodextrin that specifically encapsulates steroidal **neuromuscular blocking agents (NMBAs)** like **rocuronium** and **vecuronium**. - This encapsulation rapidly inactivates the NMBAs, leading to a dose-dependent and swift **reversal of neuromuscular blockade**. *Organophosphate poisoning* - Organophosphate poisoning is treated with **atropine** to block muscarinic effects and **pralidoxime** to reactivate inhibited acetylcholinesterase. - Sugammadex has no role in antagonizing the effects of **organophosphates** or regenerating acetylcholinesterase. *Treatment of local anaesthetic poisoning* - Local anesthetic systemic toxicity (LAST) is primarily managed with supportive care, including airway management, and the administration of **lipid emulsion therapy**. - Sugammadex does not bind to local anesthetics and therefore has no efficacy in treating local anesthetic poisoning. *Treatment of central anticholinergic syndrome* - Central anticholinergic syndrome is typically treated with **physostigmine**, an acetylcholinesterase inhibitor that can cross the blood-brain barrier. - Sugammadex is not an anticholinergic antagonist and does not affect the central nervous system to reverse anticholinergic effects.

Q: What is the drug of choice for reversing muscle relaxants after anesthesia?

Neostigmine. ***Neostigmine*** - **Neostigmine** is an **acetylcholinesterase inhibitor** that increases the amount of acetylcholine at the neuromuscular junction, thereby reversing the effects of non-depolarizing muscle relaxants. - It is often co-administered with an **anticholinergic agent** like atropine or glycopyrrolate to counteract its muscarinic side effects (e.g., bradycardia, increased secretions). *Pralidoxine* - **Pralidoxine (2-PAM)** is an **oxime cholinesterase reactivator** used primarily to treat organophosphate poisoning. - It works by regenerating acetylcholinesterase that has been inhibited by organophosphates, which is not the mechanism of action required for reversing typical muscle relaxants. *Atropine* - **Atropine** is an **anticholinergic drug** that blocks muscarinic acetylcholine receptors. - While it is often given with neostigmine to counteract muscarinic side effects like bradycardia, it does not directly reverse the neuromuscular blockade caused by muscle relaxants. *None of the options* - This option is incorrect because **neostigmine** is a well-established and commonly used drug for reversing non-depolarizing muscle relaxants.

Q: Most basic level of Health Care System in India -

Primary health care. ***Primary health care*** - **Primary health care** is the first point of contact for individuals with the health system, providing essential and accessible healthcare services - In India, it is delivered through **sub-centers** (the most peripheral unit) and **primary health centers (PHCs)**, forming the **most basic and widespread layer** of the healthcare system - This represents the foundational level of care, focusing on preventive, promotive, and basic curative services *Secondary health care* - **Secondary health care** involves more specialized services, typically provided in district hospitals or community health centers (CHCs) - It serves as a referral point from primary care for patients requiring diagnostics, specialist consultations, or inpatient care - This is a **higher level of care** than primary, not the most basic level *Tertiary health care* - **Tertiary health care** offers highly specialized and advanced medical care, often involving complex procedures, specialized investigations, and management of rare or severe diseases - Provided in medical colleges, research institutes, and super-specialty hospitals - This represents the **highest and most advanced level** of the healthcare system, not the most basic *All are same* - This option is incorrect because the Indian healthcare system is structured in a **hierarchical manner** with distinct levels - Each level (primary, secondary, and tertiary) provides different services, varying in complexity, specialization, and accessibility - Primary care is clearly the most basic level, while secondary and tertiary represent progressively higher levels of specialization

Q: Which of the following statements about the Consumer Protection Act is NOT accurate or NOT specifically mentioned in the Act?

Consumer complaints are resolved within 3-6 months.. ***Consumer complaints are resolved within 3-6 months.*** - While the Act aims for **expeditious resolution**, it does not specify a rigid 3-6 month timeframe for consumer complaint resolution. - The actual time taken can vary significantly depending on the **complexity of the case** and the **caseload of the consumer forums**. *The Act was passed in 1986.* - The **Consumer Protection Act (COPRA)** in India was indeed enacted in the year **1986**. - This statement is factually accurate regarding the **historical context** of the Act. *ESI hospitals are specifically excluded.* - The **Supreme Court of India** has ruled that services provided by **Employment State Insurance (ESI) hospitals** and other government hospitals for free are generally excluded from the purview of the Consumer Protection Act. - This exclusion is based on the premise that these services are not rendered as part of a **"contract of service"** for consideration. *Consumers have the right to safety.* - The **Consumer Protection Act** explicitly grants consumers several rights, including the **right to be protected against marketing of goods and services which are hazardous to life and property**. - This fundamental right ensures that consumers receive **safe products and services**.

Q: Amoebic liver abscess can be diagnosed by demonstrating-

Trophozoites in the pus. ***Trophozoites in the pus*** - **Amoebic liver abscesses** are caused by the invasive **trophozoite stage** of *Entamoeba histolytica*. - Demonstrating **trophozoites** in the characteristic **'anchovy paste' pus** aspirated from the abscess cavity is diagnostic. *Cysts in the pus* - **Cysts** are the **infective stage** of *Entamoeba histolytica* and are typically found in the **feces**, not in an abscess. - Cysts are responsible for transmission and survival outside the host, but they do not cause invasive disease. *Cysts in the liver* - The disease in the liver is caused by **trophozoites**, which invade the intestinal wall and then spread to the liver. - **Cysts** are never found within the liver parenchyma or abscesses. *Trophozoites in the feces* - While **trophozoites** can be found in the feces during acute amoebic dysentery, their presence alone does not confirm a liver abscess. - Furthermore, **trophozoites** are fragile and often difficult to detect in stool samples, especially once the stool has cooled.

Q: Which gene of Hepatitis B virus (HBV) is most commonly associated with mutations causing antiviral drug resistance?

P gene. ***P gene*** - The **P gene** (polymerase gene) of HBV encodes the viral reverse transcriptase which is essential for viral replication. - Mutations in the P gene can lead to **antiviral drug resistance**, particularly to nucleos(t)ide analogues. *X gene* - The **X gene** encodes the X protein (HBx), a **transcriptional transactivator** involved in viral replication and pathogenesis. - While important for viral function, it is not the primary target for antiviral therapy, and mutations are less frequently associated with drug resistance. *S gene* - The **S gene** encodes the **surface antigens (HBsAg)**, which are crucial for viral entry and immune evasion. - Mutations in the S gene can lead to **vaccine escape mutants** or alter HBsAg detection, but not directly responsible for antiviral resistance. *C gene* - The **C gene** encodes the **core protein (HBcAg)** and the precore protein (HBeAg). - These proteins are involved in **viral particle assembly** and immune modulation, but mutations in this gene are not typically associated with resistance to antiviral drugs.

Q: Pseudomembranous colitis, all are true except:

Blood in stools is a common feature. ***Blood in stools is a common feature*** - While diarrhea is a hallmark of **pseudomembranous colitis**, **bloody stools** are uncommon and, if present, suggest severe disease or an alternative diagnosis [1]. - The typical presentation involves **watery diarrhea**, abdominal cramps, and fever, not usually overt bleeding [1]. *Toxin A is responsible for clinical manifestation* - **Toxin A (TcdA)** is one of the primary exotoxins produced by *Clostridioides difficile* and contributes significantly to the **inflammation** and fluid secretion seen in pseudomembranous colitis. - It acts as an **enterotoxin**, causing fluid secretion and mucosal damage in the colon [1]. *Summit lesions are early histopathological findings* - **Summit lesions**, also known as "summit pseudomembranes" or **"volcano lesions"**, refer to characteristic histological findings where inflammatory exudates effuse from the tips of damaged crypts. - These are typical early findings in pseudomembranous colitis, demonstrating the focal nature of the **mucosal injury**. *Toxin B is responsible for clinical manifestation* - **Toxin B (TcdB)** is another key exotoxin produced by *Clostridioides difficile*, and it is considered even more **cytotoxic** than Toxin A [1]. - It causes significant **cell damage** and **apoptosis**, playing a crucial role in the development of the pseudomembranes and clinical symptoms [1].

Q: What is the role of Anandamide in the human body?

Cannabinoid neurotransmitter. ***Cannabinoid neurotransmitter*** - **Anandamide** is an **endogenous cannabinoid neurotransmitter** that binds to **CB1** and **CB2 receptors**. - It plays a role in **pain modulation**, **appetite stimulation**, and **memory regulation**. *Opioid* - **Opioids** bind to **opioid receptors** (mu, delta, kappa) and are known for their **analgesic** and **euphoric effects**. - Examples include **morphine** and **endorphins**, which are chemically distinct from anandamide and have different receptor targets. *CK 1 antagonist* - This option refers to a **cholecystokinin 1 (CCK1) receptor antagonist**, which would block the effects of **CCK**. - **CCK** is a hormone involved in **digestion** and **satiety**, and its role is unrelated to anandamide. *D2 blocker* - A **D2 blocker** is an agent that antagonizes the **dopamine D2 receptor**. - These are typically **antipsychotic medications** that modulate **dopamine pathways** in the brain, unrelated to the function of anandamide.

Q: What does the acronym NSABP represent in the context of cancer research?

National Surgical Adjuvant Breast and Bowel Project. ***National surgical adjuvant for breast and bowel project*** - **NSABP** stands for **National Surgical Adjuvant Breast and Bowel Project**. - It is a prominent research organization focused on conducting clinical trials for the prevention and treatment of breast and colorectal cancer. *National surgical adjuvant for breast project* - This option is incomplete as it omits the "bowel" component of the organization's focus. - The NSABP's research scope extends beyond just breast cancer to include **colorectal cancer**. *National surgical adjuvant for brain and breast* - This option incorrectly includes "brain" and omits "bowel" from the acronym. - The NSABP's primary research areas are **breast and bowel (colorectal) cancers**, not brain cancer. *National surgical adjuvant for bowel and brain* - This option incorrectly includes "brain" and omits "breast" from the acronym. - The NSABP is known for its extensive work in both **breast and colorectal cancer research**.

Question 1

What is the primary clinical use of Sugammadex in anesthesia?

Accepted Answer

Reversal of NM blockers

Answer

Organophosphate poisoning

Answer

Treatment of local anaesthetic poisoning

Answer

Treatment of central anticholinergic syndrome

Question 2

What is the drug of choice for reversing muscle relaxants after anesthesia?

Accepted Answer

Neostigmine

Answer

Pralidoxine

Answer

Atropine

Answer

None of the options

Question 3

Most basic level of Health Care System in India -

Accepted Answer

Primary health care

Answer

Secondary health care

Answer

Tertiary health care

Answer

All are same

Question 4

What is the punishment under the Dowry Prohibition Act, 1961?

Accepted Answer

Imprisonment for 6 months to 2 years or fine up to Rs 10,000 or both

Answer

Imprisonment for 1 year, Rs 25,000

Answer

Imprisonment for 1 year, Rs 15,000

Answer

Imprisonment for 5 years, Rs 25,000

Question 5

Which of the following statements about the Consumer Protection Act is NOT accurate or NOT specifically mentioned in the Act?

Accepted Answer

Consumer complaints are resolved within 3-6 months.

Answer

The Act was passed in 1986.

Answer

Consumers have the right to safety.

Answer

ESI hospitals are specifically excluded.

Question 6

Amoebic liver abscess can be diagnosed by demonstrating-

Accepted Answer

Trophozoites in the pus

Answer

Trophozoites in the feces

Answer

Cysts in the pus

Answer

Cysts in the liver

Question 7

Which gene of Hepatitis B virus (HBV) is most commonly associated with mutations causing antiviral drug resistance?

Accepted Answer

P gene

Answer

X gene

Answer

S gene

Answer

C gene

Question 8

Pseudomembranous colitis, all are true except:

Accepted Answer

Blood in stools is a common feature

Answer

Toxin A is responsible for clinical manifestation

Answer

Summit lesions are early histopathological findings

Answer

Toxin B is responsible for clinical manifestation

Question 9

What is the role of Anandamide in the human body?

Accepted Answer

Cannabinoid neurotransmitter

Answer

Opioid

Answer

D2 blocker

Answer

CCK1 antagonist

Question 10

What does the acronym NSABP represent in the context of cancer research?

Accepted Answer

National Surgical Adjuvant Breast and Bowel Project

Answer

National surgical adjuvant for brain and breast

Answer

National surgical adjuvant for bowel and brain

Answer

National surgical adjuvant for breast project

NEET-PG 2013

Anesthesiology

Community Medicine

Forensic Medicine

Microbiology

Pathology

Physiology

Surgery