ENT
2 questionsHearing loss of 65dB, what is the grade of deafness?
What is the most common cause of ASOM?
NEET-PG 2013 - ENT NEET-PG Practice Questions and MCQs
Question 451: Hearing loss of 65dB, what is the grade of deafness?
- A. Mild
- B. Moderate
- C. Severe
- D. Moderately severe (Correct Answer)
Explanation: ***Moderately severe*** - A hearing loss of **65 dB** falls within the range defined as moderately severe. - The moderately severe range typically spans from **56 dB to 70 dB** in conventional audiometric classifications. *Mild* - **Mild hearing loss** is characterized by a threshold between **26 dB and 40 dB**. - Individuals with mild hearing loss may struggle with soft sounds or speech in noisy environments. *Moderate* - **Moderate hearing loss** is defined by a threshold between **41 dB and 55 dB**. - This level of loss causes difficulty understanding normal conversation without amplification. *Severe* - **Severe hearing loss** is characterized by a threshold between **71 dB and 90 dB**. - Individuals with severe hearing loss often require powerful hearing aids or other assistive listening devices.
Question 452: What is the most common cause of ASOM?
- A. Meningococci
- B. Pneumococci (Correct Answer)
- C. H. influenzae
- D. Moraxella catarrhalis
Explanation: ***Pneumococci*** - **_Streptococcus pneumoniae_ (Pneumococci)** is the **most common bacterial cause** of Acute Suppurative Otitis Media (ASOM) in all age groups, particularly in young children. - It accounts for an estimated 25-50% of all ASOM cases, often leading to significant inflammation and **purulent discharge**. *Meningococci* - **_Neisseria meningitidis_ (Meningococci)** is rarely a cause of ASOM. - It is primarily known for causing **meningitis** and **sepsis**, not typically middle ear infections. *H. influenzae* - **_Haemophilus influenzae_ (non-typable)** is the **second most common cause** of ASOM, accounting for 20-40% of cases. - While significant, it is generally less prevalent than _Streptococcus pneumoniae_. *Moraxella catarrhalis* - **_Moraxella catarrhalis_** is another common causative agent of ASOM, responsible for 10-20% of cases. - It is frequently seen in conjunction with other pathogens but is not the most common on its own.
Internal Medicine
1 questionsTreatment of choice for prinzmetal's angina
NEET-PG 2013 - Internal Medicine NEET-PG Practice Questions and MCQs
Question 451: Treatment of choice for prinzmetal's angina
- A. Nitroglycerin
- B. Prazosin
- C. Beta-blockers
- D. Calcium Channel Blockers (CCBs) (Correct Answer)
Explanation: ***Calcium Channel Blockers (CCBs)*** - **Dihydropyridine** CCBs like nifedipine or amlodipine, and **non-dihydropyridine** CCBs like diltiazem or verapamil, are the **first-line agents** for Prinzmetal's angina [1]. - They work by **relaxing coronary smooth muscle**, preventing the vasospasm that causes the angina [1]. *Nitroglycerin* - **Nitroglycerin is effective** for acute relief of Prinzmetal's angina symptoms due to its **vasodilatory properties**. - However, it's typically used as **rescue therapy** and not as a long-term preventative treatment. *Beta-blockers* - Beta-blockers are **contraindicated** in Prinzmetal's angina as they can **worsen coronary vasospasm** by blocking beta-2 mediated vasodilation, leaving unopposed alpha-1 vasoconstriction [2]. - They can increase the **frequency and severity of attacks**. *Prazosin* - Prazosin is an **alpha-1 adrenergic blocker** used primarily for **hypertension** and benign prostatic hyperplasia. - While it can cause vasodilation, it is **not the treatment of choice** for Prinzmetal's angina and is less effective than CCBs in preventing coronary spasm.
Pharmacology
7 questionsWhich drug is used for sympathectomy in experimental animals?
What is a common side effect of salmeterol?
Which of the following is NOT a function of Prostaglandin E1 (PGE1)?
Which of the following is a renin inhibitor?
In which of the following conditions is Verapamil not typically used?
Which of the following is NOT a side effect of digitalis?
Nesiritide causes vasodilation through?
NEET-PG 2013 - Pharmacology NEET-PG Practice Questions and MCQs
Question 451: Which drug is used for sympathectomy in experimental animals?
- A. Guanethidine (Correct Answer)
- B. Atropine
- C. Diazoxide
- D. Thebaine
Explanation: ***Guanethidine*** - **Guanethidine** is a potent **adrenergic neuron blocking drug** that is taken up by noradrenergic neurons and prevents the release of norepinephrine, leading to a chemical sympathectomy. - In experimental animal models, it is used to induce a **pharmacological sympathectomy** to study the effects of sympathetic nervous system blockade on various physiological processes. *Atropine* - **Atropine** is a **muscarinic acetylcholine receptor antagonist** that blocks the effects of acetylcholine at parasympathetic postganglionic terminals. - It is primarily used to block **parasympathetic responses**, not sympathetic ones, and therefore would not induce a sympathectomy. *Diazoxide* - **Diazoxide** is a direct **arteriolar vasodilator** that works by opening potassium channels in vascular smooth muscle. - It is used to quickly reduce blood pressure in **hypertensive emergencies** and for treating hypoglycemia due to insulin oversecretion, and does not cause sympathectomy. *Thebaine* - **Thebaine** is an **opioid alkaloid** found in opium, structurally similar to morphine and codeine, but with primarily stimulatory rather than depressant effects. - It acts as a **convulsant** and is used as a precursor in the synthesis of other opioids, but has no role in causing sympathectomy.
Question 452: What is a common side effect of salmeterol?
- A. Tremors (Correct Answer)
- B. Seizures
- C. Hypertension
- D. Hyperkalemia
Explanation: ***Tremors*** - **Salmeterol** is a **long-acting beta-2 adrenergic agonist (LABA)** that can stimulate beta-2 receptors in skeletal muscle, leading to **fine muscle tremors**. - This side effect is dose-dependent and more common with higher doses or in patients sensitive to sympathomimetic effects. *Seizures* - **Seizures** are a rare and atypical side effect of **salmeterol** and other beta-2 agonists; they are not considered a common adverse event. - While systemic absorption can occur, the central nervous system effects leading to seizures are not frequently observed. *Hypertension* - While beta-2 agonists can cause a slight increase in **heart rate** due to systemic absorption, **hypertension** is not a common side effect of inhaled salmeterol. - Other cardiovascular effects like palpitations can occur, but significant or sustained hypertension is rare. *Hyperkalemia* - **Hyperkalemia** (elevated potassium) is not a side effect of **salmeterol**; in fact, beta-2 agonists commonly cause the **opposite effect - hypokalemia** (decreased serum potassium). - Beta-2 receptor stimulation activates Na⁺-K⁺-ATPase pumps, driving potassium from serum into cells, causing transient hypokalemia. - This effect is clinically relevant and requires monitoring, especially when combined with other medications that lower potassium.
Question 453: Which of the following is NOT a function of Prostaglandin E1 (PGE1)?
- A. Plays a role in initiating puberty (Correct Answer)
- B. Modulates inflammatory responses
- C. Used in the management of erectile dysfunction
- D. Maintains the patency of the ductus arteriosus
Explanation: ***Plays a role in initiating puberty*** - **Prostaglandin E1 (PGE1)** is primarily involved in smooth muscle relaxation, vasodilation, and inflammation, and does not have a direct role in initiating **puberty**. - The initiation of puberty is mainly controlled by the **hypothalamic-pituitary-gonadal (HPG) axis** and surge of **gonadotropin-releasing hormone (GnRH)**. *Used in the management of erectile dysfunction* - **PGE1 formulations** (alprostadil) are used as a topical or intracavernosal injection to treat **erectile dysfunction** by inducing vasodilation in the penis. - Its vasodilatory effects increase blood flow to the corpora cavernosa, leading to **penile erection**. *Modulates inflammatory responses* - **PGE1** is involved in **inflammatory processes**, often exerting both pro- and anti-inflammatory effects depending on the context and specific receptors activated. - It can help to **reduce inflammation** and pain, as well as influencing immune cell function. *Maintains the patency of the ductus arteriosus* - In newborns with **congenital heart defects**, **PGE1** is administered to maintain the **patency of the ductus arteriosus**, allowing for blood flow between the aorta and pulmonary artery. - This is crucial for conditions where pulmonary or systemic blood flow is dependent on a patent ductus, bridging the infant to surgery or other interventions.
Question 454: Which of the following is a renin inhibitor?
- A. Losartan
- B. Benazepril
- C. Remikiren (Correct Answer)
- D. Imidapril
Explanation: **Remikiren** - **Remikiren** is a direct **renin inhibitor** that acts by binding to the active site of renin, preventing its interaction with angiotensinogen. - This inhibition reduces the formation of **angiotensin I** and subsequently **angiotensin II**, leading to decreased blood pressure. *Losartan* - **Losartan** is an **Angiotensin II Receptor Blocker (ARB)**, meaning it blocks AT1 receptors, preventing angiotensin II from binding. - It does not inhibit renin activity directly but rather acts downstream in the **renin-angiotensin-aldosterone system (RAAS)**. *Benazepril* - **Benazepril** is an **Angiotensin-Converting Enzyme (ACE) inhibitor**, which blocks the enzyme responsible for converting **angiotensin I** to **angiotensin II**. - It does not directly inhibit renin production or activity. *Imidapril* - **Imidapril** is also an **Angiotensin-Converting Enzyme (ACE) inhibitor**, similar to benazepril. - Its mechanism of action involves inhibiting ACE, thereby reducing **angiotensin II** levels, rather than directly inhibiting renin.
Question 455: In which of the following conditions is Verapamil not typically used?
- A. Angina pectoris
- B. Atrial fibrillation
- C. Ventricular tachycardia (Correct Answer)
- D. Hypertension
Explanation: ***Ventricular tachycardia*** - Verapamil, a **non-dihydropyridine calcium channel blocker**, can worsen hemodynamics in patients with **ventricular tachycardia (VT)** by causing profound hypotension or precipitating cardiac arrest. - VT often requires prompt treatment with **antiarrhythmics like amiodarone** or **electrical cardioversion**, as it can be life-threatening. - Verapamil is **contraindicated in VT** due to its negative inotropic effects and risk of hemodynamic collapse. *Angina pectoris* - Verapamil is effectively used to treat angina pectoris by **decreasing myocardial oxygen demand** through negative chronotropic and inotropic effects, and by causing **coronary vasodilation**, improving blood flow. - Its effects help to reduce the frequency and severity of anginal episodes, particularly in **stable angina**. *Atrial fibrillation* - Verapamil is commonly used for **rate control in atrial fibrillation** by **slowing conduction through the AV node**, which decreases the ventricular response rate. - It helps to manage symptoms and prevent complications related to rapid heart rates in this arrhythmia. *Hypertension* - Verapamil is used in the treatment of **hypertension** through its vasodilatory effects and reduction in peripheral vascular resistance. - It is particularly useful in patients who cannot tolerate other antihypertensive agents or as part of combination therapy.
Question 456: Which of the following is NOT a side effect of digitalis?
- A. Nausea and vomiting
- B. Ventricular Bigeminy
- C. Vasodilatation (Correct Answer)
- D. Ventricular tachycardia
Explanation: **Vasodilatation** - **Digitalis**, primarily digoxin, is known for its **positive inotropic effect**, increasing myocardial contractility, and for its **vasoconstrictive properties** at higher doses due to sympathetic activation and direct smooth muscle effects, not vasodilatation. - While it can indirectly improve cardiac output and thus tissue perfusion, its direct vascular effects do not typically include widespread vasodilatation. *Ventricular tachycardia* - **Digitalis toxicity** can lead to various arrhythmias, including **ventricular tachycardia**, which is a potentially life-threatening side effect. - This occurs due to increased automaticity and delayed afterdepolarizations in ventricular myocytes. *Nausea and vomiting* - **Gastrointestinal symptoms** such as **nausea and vomiting** are common early signs of digitalis toxicity. - These effects are thought to be mediated by the drug's action on the chemoreceptor trigger zone in the brainstem. *Ventricular Bigeminy* - **Ventricular bigeminy**, characterized by alternating normal and premature ventricular beats, is another classic manifestation of **digitalis toxicity**. - This arrhythmia results from enhanced automaticity and altered conduction properties in the ventricles.
Question 457: Nesiritide causes vasodilation through?
- A. ATP
- B. Cyclic adenosine monophosphate (cAMP)
- C. K+ ions
- D. Guanosine 3',5'-cyclic monophosphate (cGMP) (Correct Answer)
Explanation: ***Guanosine 3',5'-cyclic monophosphate (cGMP)*** - **Nesiritide** is a synthetic **B-type natriuretic peptide (BNP)** that acts as a potent vasodilator [2]. - It works by binding to **guanylyl cyclase receptors**, leading to an increase in intracellular **cGMP**, which promotes smooth muscle relaxation [1], [2]. *Cyclic adenosine monophosphate (cAMP)* - While **cAMP** is a crucial second messenger in various cellular processes and can mediate some forms of vasodilation, it is primarily associated with **beta-adrenergic receptor activation**, not the mechanism of action of nesiritide. - Nesiritide's pathway is distinct from those involving **cAMP-mediated** relaxation, which often involves different kinases and protein phosphorylation. *ATP* - **ATP** (adenosine triphosphate) is the primary **energy currency** of the cell and is involved in numerous cellular functions, including muscle contraction and relaxation, but it is not a direct mediator of nesiritide's vasodilatory effects. - Though ATP can be broken down to produce **adenosine**, which has vasodilatory properties, this is not the specific mechanism through which nesiritide causes vasodilation. *K+ ions* - Changes in **potassium ion (K+)** flux across cell membranes are essential for regulating vascular tone, as K+ channel activation can lead to hyperpolarization and relaxation of smooth muscle. - However, **nesiritide's primary mechanism** of action does not involve direct modulation of K+ channels; its vasodilatory effects are mediated by the **cGMP pathway** [2].