Internal Medicine
1 questionsWhich of the following statements is MOST accurate regarding herpes encephalitis?
NEET-PG 2012 - Internal Medicine NEET-PG Practice Questions and MCQs
Question 871: Which of the following statements is MOST accurate regarding herpes encephalitis?
- A. Focal neurological symptoms are common.
- B. EEG findings are nonspecific and not diagnostic.
- C. The temporal lobe is commonly involved. (Correct Answer)
- D. MRI is a key diagnostic tool.
Explanation: ***The temporal lobe is commonly involved.*** - **Herpes simplex encephalitis (HSE)** characteristically targets the **temporal lobes** [1] and **orbitofrontal cortex**, leading to specific neurological deficits. - This predilection for the temporal lobes often results in symptoms such as **aphasia**, **seizures**, and **memory disturbances** [1]. *Focal neurological symptoms are common.* - While focal neurological symptoms such as **aphasia**, **hemiparesis**, and **seizures** are indeed common in HSE [1], this statement is less specific than the involvement of the temporal lobe. - The **localization** of the infection to the temporal lobes explains why these focal symptoms are so prevalent [1]. *MRI is a key diagnostic tool.* - **MRI findings**, particularly **T2-weighted** and **FLAIR sequences**, showing **edema** and **hemorrhage** in the temporal lobes and insular cortex, are highly suggestive of HSE. - However, the most definitive diagnostic tool remains the detection of **HSV DNA** in the **cerebrospinal fluid (CSF)** via **PCR**. *EEG findings are nonspecific and not diagnostic.* - **EEG** in HSE often shows **periodic lateralizing epileptiform discharges (PLEDs)** or **focal slowing** primarily over the temporal lobes, which are highly suggestive, although not entirely diagnostic on their own. - These findings can help guide further investigation and support a clinical diagnosis in conjunction with other tests.
Obstetrics and Gynecology
1 questionsWhich of the following is associated with macrosomia?
NEET-PG 2012 - Obstetrics and Gynecology NEET-PG Practice Questions and MCQs
Question 871: Which of the following is associated with macrosomia?
- A. None of the options
- B. Gestational diabetes mellitus (Correct Answer)
- C. Hypothyroidism
- D. Maternal anemia
Explanation: ***Gestational diabetes mellitus*** - **Gestational diabetes mellitus (GDM)** is a common cause of macrosomia because high maternal glucose levels lead to increased fetal insulin production, which promotes growth and fat deposition. - The **hyperglycemic environment** in GDM stimulates fetal overgrowth, resulting in larger-than-average babies. *Hypothyroidism* - **Maternal hypothyroidism** is typically associated with **fetal growth restriction** and lower birth weight, not macrosomia. - Undiagnosed or poorly controlled hypothyroidism can lead to complications such as **preterm labor** and **preeclampsia**, but not increased fetal size. *None of the options* - This option is incorrect because **gestational diabetes mellitus** is directly associated with macrosomia. - There is a clear and well-documented link between maternal hyperglycemia and increased fetal growth. *Maternal anemia* - **Maternal anemia**, especially severe anemia, is generally associated with an **increased risk of fetal growth restriction** and **low birth weight**. - Anemia limits oxygen and nutrient delivery to the fetus, thereby hindering optimal growth.
Orthopaedics
2 questionsProximal humerus fracture which has maximum chances of avascular necrosis
What is a Pulled Elbow?
NEET-PG 2012 - Orthopaedics NEET-PG Practice Questions and MCQs
Question 871: Proximal humerus fracture which has maximum chances of avascular necrosis
- A. One part
- B. Two part
- C. Three part
- D. Four part (Correct Answer)
Explanation: ***Four part fracture*** - A **four-part proximal humerus fracture** typically involves displacement of the humeral head, greater tuberosity, lesser tuberosity, and humeral shaft. - This extensive displacement significantly disrupts the **blood supply** to the humeral head, specifically the **arcuate artery** and its branches, leading to a high risk of **avascular necrosis**. *One part fracture* - A **one-part fracture** indicates that the fracture fragments are minimally displaced (<1 cm or <45° angulation). - The **blood supply** to the humeral head remains largely intact, resulting in a very low risk of avascular necrosis. *Two part fracture* - A **two-part fracture** involves displacement of one major fragment (e.g., surgical neck or tuberosity) from the humeral head. - While there is some disruption, the overall risk of **avascular necrosis** is lower compared to more complex fractures. *Three part fracture* - A **three-part fracture** involves separate displacement of the humeral head and two tuberosities. - This fracture pattern causes more significant disruption to the **vascularity** of the humeral head than two-part fractures but generally less than four-part fractures.
Question 872: What is a Pulled Elbow?
- A. Subluxation of proximal radio ulnar joint
- B. Complete separation of the elbow joint
- C. No injury present
- D. Partial dislocation of the radial head (Correct Answer)
Explanation: ***Partial dislocation of the radial head*** - A pulled elbow, also known as **nursemaid's elbow**, specifically refers to a **subluxation of the radial head** from the annular ligament. - This injury typically occurs in young children when their arm is suddenly pulled or jerked, causing the **radial head** to slip out of the **annular ligament**. *Complete separation of the elbow joint* - A complete separation of the elbow joint would involve a **full dislocation** of the humeroulnar or humeroradial joints, a much more severe injury than a pulled elbow. - This would present with more significant deformity and instability compared to the subtle presentation of a pulled elbow. *Subluxation of proximal radio ulnar joint* - While the injury involves the radius and ulna, the specific subluxation in a pulled elbow is that of the **radial head** at the **humero-radial joint**, not primarily the proximal radio-ulnar joint itself. - The focus is on the annular ligament's integrity around the radial head, rather than direct forces acting on the proximal radio-ulnar articulation. *No injury present* - A pulled elbow is a recognized and common **pediatric orthopedic injury** requiring intervention to reduce the radial head. - The child will typically present with pain, refusal to use the affected arm, and a characteristic holding posture.
Pathology
1 questionsThe immunoglobulin most commonly involved in Multiple Myeloma is:
NEET-PG 2012 - Pathology NEET-PG Practice Questions and MCQs
Question 871: The immunoglobulin most commonly involved in Multiple Myeloma is:
- A. IgG (Correct Answer)
- B. IgM
- C. IgA
- D. IgD
Explanation: ***IgG*** - In Multiple Myeloma, the most commonly involved immunoglobulin is **IgG**, which is often produced in excess by malignant plasma cells [1][2]. - The presence of **monoclonal IgG** in serum is a key indicator of this malignancy, evident in diagnostic tests like serum protein electrophoresis. *IgM* - While **elevated IgM** levels can occur in other conditions like Waldenström's macroglobulinemia, it is not typically associated with Multiple Myeloma [2]. - IgM is produced by a different type of plasma cell and does not reflect the classic presentation of Multiple Myeloma. *IgA* - Although **IgA** can be involved in some cases of Multiple Myeloma, it is much less common than IgG [1][2]. - Patients with predominately **IgA Multiple Myeloma** are relatively rare compared to those with IgG. *IgD* - **IgD** myeloma is a very rare type of Multiple Myeloma, accounting for less than 2% of cases [1][2]. - It is not typically associated with the classic symptoms and conditions that characterize the more common IgG or IgA forms. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus, pp. 608-609. [2] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Blood And Bone Marrow Disease, pp. 616-617.
Pediatrics
2 questionsUpper segment to lower segment ratio in a 3-year-old child is:
What is the recommended rate for blood transfusion in neonates?
NEET-PG 2012 - Pediatrics NEET-PG Practice Questions and MCQs
Question 871: Upper segment to lower segment ratio in a 3-year-old child is:
- A. 1.2:1
- B. 1.3:1 (Correct Answer)
- C. 1.4:1
- D. 1.6:1
Explanation: ***1.3:1*** - At birth, the upper segment to lower segment ratio is around **1.7:1**, indicating proportionally longer trunks. - By the age of **3 years**, this ratio typically decreases to approximately **1.3:1** as the lower limbs grow more rapidly. *1.2:1* - This ratio is typically observed in **older children** or young adults, as lower limb growth catches up further. - A ratio of 1.2:1 would suggest more **proportional body segments** than expected for a 3-year-old child. *1.4:1* - This ratio is closer to that of a **younger infant** or toddler, as the lower segments are still relatively shorter. - A 3-year-old would generally have experienced more **lower limb growth**, reducing this ratio further. *1.6:1* - This ratio is characteristic of a **newborn or very young infant**, where the upper body and head are significantly larger relative to the legs. - It would be **abnormal** for a 3-year-old to still have such a high ratio, indicating a disproportional growth pattern.
Question 872: What is the recommended rate for blood transfusion in neonates?
- A. 1-5 ml/min (Correct Answer)
- B. 10-15 ml/min
- C. 15-20 ml/min
- D. 5-10 ml/min
Explanation: ***1-5 ml/min*** - The recommended rate for blood transfusion in neonates is **1-5 ml/min** to prevent **circulatory overload** and other complications. - Slower rates are crucial for neonates due to their limited cardiovascular reserves and smaller blood volume. *5-10 ml/min* - This rate is generally **too fast** for routine neonatal blood transfusions, increasing the risk of **fluid overload** and **cardiac strain**. - Rapid administration can lead to complications such as **necrotizing enterocolitis (NEC)** or **respiratory distress**. *10-15 ml/min* - Administering blood at this rate in neonates is **contraindicated** due to the high risk of **cardiovascular compromise**. - It could quickly overwhelm the neonate's circulatory system, leading to severe adverse events. *15-20 ml/min* - This rate is significantly **too rapid** for any neonatal blood transfusion and would almost certainly result in **severe volume overload** and potential cardiac arrest. - Such high rates are only rarely considered in extreme emergency situations, like massive hemorrhage with specific considerations and monitoring.
Psychiatry
2 questionsWhat term describes repetitive, intrusive thoughts that cause significant distress or anxiety?
Which of the following is a first-line treatment for bipolar affective (manic-depressive) disorder:
NEET-PG 2012 - Psychiatry NEET-PG Practice Questions and MCQs
Question 871: What term describes repetitive, intrusive thoughts that cause significant distress or anxiety?
- A. Phobia
- B. Obsession (Correct Answer)
- C. Compulsion
- D. Anxiety
Explanation: ***Obsession*** - An **obsession** is defined by the presence of **recurrent and persistent thoughts, urges, or images** that are experienced as intrusive and unwanted, causing significant anxiety or distress. - These thoughts are often recognized as products of one's own mind, and individuals typically attempt to ignore, suppress, or neutralize them. *Phobia* - A **phobia** is an intense, irrational fear of a specific object or situation that poses little or no actual danger. - Unlike obsessions, phobias are typically related to external stimuli and do not primarily involve intrusive thoughts. *Compulsion* - A **compulsion** is a repetitive behavior (e.g., hand washing, checking) or mental act (e.g., praying, counting) that an individual feels driven to perform in response to an obsession. - Compulsions are often aimed at preventing or reducing anxiety or distress, or preventing some dreaded event or situation. *Anxiety* - **Anxiety** is a general term for a feeling of worry, nervousness, or unease, typically about an event or something with an uncertain outcome. - While obsessions cause anxiety, "anxiety" itself is a broad emotional state, not specifically the intrusive thoughts described.
Question 872: Which of the following is a first-line treatment for bipolar affective (manic-depressive) disorder:
- A. Chlorpromazine
- B. Haloperidol
- C. Diazepam
- D. Lithium carbonate (Correct Answer)
Explanation: **Lithium carbonate** - **Lithium** is a well-established and highly effective **mood stabilizer**, considered a first-line treatment for managing both **manic** and **depressive episodes** in bipolar disorder. - It helps prevent recurrent episodes and reduces the severity of mood swings, acting as a prophylactic agent. *Chlorpromazine* - **Chlorpromazine** is a **first-generation antipsychotic** that is primarily used to treat **schizophrenia** and other psychotic disorders. - While it can be used acutely to manage severe manic agitation, it is not a first-line agent for the long-term mood stabilization characteristic of bipolar disorder. *Haloperidol* - **Haloperidol** is another **first-generation antipsychotic** often used for acute treatment of **psychotic symptoms** or severe agitation, including in mania. - It is not a primary long-term mood stabilizer for bipolar disorder due to its side effect profile and lack of efficacy in preventing future mood episodes compared to lithium. *Diazepam* - **Diazepam** is a **benzodiazepine** primarily used for treating **anxiety**, muscle spasms, and acute seizures. - While it can help manage acute agitation and insomnia during a manic episode, it does not have mood-stabilizing properties and is not a long-term treatment for bipolar disorder.
Surgery
1 questionsIn Congenital Diaphragmatic Hernia (CDH), the most commonly associated anomaly affects the
NEET-PG 2012 - Surgery NEET-PG Practice Questions and MCQs
Question 871: In Congenital Diaphragmatic Hernia (CDH), the most commonly associated anomaly affects the
- A. Congenital heart defects (Correct Answer)
- B. Anomalies of the urinary tract
- C. Anomalies of the skull
- D. Craniofacial anomalies
Explanation: ***Congenital heart defects*** - **Congenital diaphragmatic hernia (CDH)** is frequently associated with other congenital anomalies. - **Cardiac malformations** are the most common co-occurring defects, affecting a significant proportion of CDH patients. *Anomalies of the urinary tract* - While **urogenital anomalies** can occur with CDH, they are less prevalent than congenital heart defects. - These typically include conditions like **renal agenesis** or **hydronephrosis**. *Anomalies of the skull* - **Skull anomalies** are not a primary or common association with congenital diaphragmatic hernia. - Genetic syndromes associated with both CDH and skull anomalies are relatively rare. *Craniofacial anomalies* - **Craniofacial anomalies**, such as **cleft lip/palate**, can occur with CDH but are less common than cardiac anomalies. - These are often seen within the context of specific genetic syndromes.