Dermatology
1 questionsWhich of the following pairs of conditions is incorrectly matched?
NEET-PG 2012 - Dermatology NEET-PG Practice Questions and MCQs
Question 1121: Which of the following pairs of conditions is incorrectly matched?
- A. Erythema gyratum repens - malignancy
- B. Erythema marginatum - rheumatic fever
- C. Necrotic acral erythema - HCV
- D. Erythema chronicum migrans - malignancy (Correct Answer)
Explanation: ***Erythema chronicum migrans - malignancy*** - **Erythema chronicum migrans** is the characteristic skin lesion of **Lyme disease**, caused by the bacterium *Borrelia burgdorferi*, transmitted by ticks. - It is not associated with malignancy; rather, its presence indicates a **bacterial infection** requiring antibiotic treatment. *Erythema marginatum - rheumatic fever* - **Erythema marginatum** is a **major diagnostic criterion** for **rheumatic fever**, a post-streptococcal inflammatory disease. - The rash is characterized by non-itchy, pink or red macules with raised, serpiginous borders that spread outwards, often transient. *Erythema gyratum repens - malignancy* - **Erythema gyratum repens** is a rare **paraneoplastic dermatosis** strongly associated with various internal malignancies, most commonly lung cancer. - It presents as a characteristic **wood-grain-like pattern** of concentric, migratory erythematous bands. *Necrotic acral erythema - HCV* - **Necrotic acral erythema** is a skin condition that predominantly affects the hands and feet and has a strong association with **hepatitis C virus (HCV) infection**. - It presents with violaceous plaques that can ulcerate and become necrotic, often in patients with chronic HCV.
Internal Medicine
7 questionsA person experiences asthma attacks more than twice during the day and at least once during the night. What is the most likely classification of their asthma?
Which biomarker is typically elevated in the plasma of patients with chronic heart disease?
Which of the following is a characteristic feature of primary Sjogren's syndrome?
All the following are true about multiple myeloma except for which of the following?
Which of the following is a characteristic feature of myasthenia gravis?
Anomic aphasia is due to defect in
What is the preferred test for confirming H. pylori eradication?
NEET-PG 2012 - Internal Medicine NEET-PG Practice Questions and MCQs
Question 1121: A person experiences asthma attacks more than twice during the day and at least once during the night. What is the most likely classification of their asthma?
- A. Intermittent asthma
- B. Mild persistent asthma
- C. Moderate persistent asthma
- D. Severe persistent asthma (Correct Answer)
Explanation: ***Severe persistent asthma*** - This classification is characterized by **frequent symptoms**, specifically asthma attacks occurring more than twice daily and at least once nightly. - Individuals with severe persistent asthma often experience significant limitations in their daily activities and may have a **FEV1 (forced expiratory volume in 1 second)** less than 60% of predicted. *Intermittent asthma* - This classification is characterized by symptoms occurring less than two days per week and **nighttime awakenings less than two times per month**. - Symptoms are generally well-controlled with a short-acting beta-agonist (SABA) as needed. *Mild persistent asthma* - Patients with mild persistent asthma typically experience symptoms more than twice a week but **less than once a day**, and **nighttime awakenings 3-4 times per month**. - Their lung function (FEV1) is usually 80% or more of predicted. *Moderate persistent asthma* - This category involves daily symptoms and **nighttime awakenings more than once per week but not nightly**. - Lung function (FEV1) in moderate persistent asthma typically falls between 60% and 80% of predicted.
Question 1122: Which biomarker is typically elevated in the plasma of patients with chronic heart disease?
- A. Endothelin-1
- B. Troponin T
- C. B-type natriuretic peptide (BNP) (Correct Answer)
- D. Cortisol
Explanation: ***B-type natriuretic peptide (BNP)*** - **BNP** is a hormone secreted by **ventricular cardiomyocytes** in response to increased wall stretch and pressure overload, making it a strong indicator of **myocardial stress** and **chronic heart failure** [1]. - Elevated levels correlate with the **severity of heart failure**, aiding in diagnosis and prognosis [1]. *Endothelin-1* - **Endothelin-1** is a potent **vasoconstrictor** involved in vascular tone regulation and endothelial dysfunction. - While it can be elevated in conditions like **pulmonary hypertension** and **atherosclerosis**, it is not a primary diagnostic biomarker for chronic heart disease in general. *Troponin T* - **Troponin T** is a cardiac-specific protein that is released into the bloodstream following **myocardial injury or necrosis**. - While it is a crucial biomarker for **acute coronary syndromes** (e.g., heart attack), persistently elevated levels are not typical for stable chronic heart disease unless there is ongoing subclinical myocardial damage. *Cortisol* - **Cortisol** is a **stress hormone** produced by the adrenal glands, involved in metabolism, immune response, and blood pressure regulation. - While chronic stress can impact cardiovascular health, cortisol itself is not a specific diagnostic biomarker for chronic heart disease.
Question 1123: Which of the following is a characteristic feature of primary Sjogren's syndrome?
- A. Can occur in children
- B. Increased complement C4 is associated with thymoma
- C. Can be associated with rheumatoid arthritis
- D. Enlargement of salivary glands (Correct Answer)
Explanation: ***Enlargement of salivary glands*** - **Sjögren's syndrome** is characterized by chronic inflammation of **exocrine glands**, leading to swelling and dysfunction, most notably in the **parotid** and **submandibular glands**. - This glandular enlargement often presents as recurrent or persistent **bilateral swelling** of the major salivary glands. *Can occur in children* - While possible, Sjögren's syndrome is predominantly a disease of **adults**, with incidence peaking in individuals between **40 and 60 years old**. - **Juvenile Sjögren's syndrome** is rare and typically presents with more variable symptoms, making it less of a characteristic feature of the primary disease in the general population. *Increased complement C4 is associated with thymoma* - **Increased complement C4** levels are generally not associated with Sjögren's syndrome; instead, **hypocomplementemia** (low C4) can be seen in some patients, indicating immune complex activity. - **Thymoma** is primarily linked to **myasthenia gravis** and other paraneoplastic syndromes, not a direct or characteristic association with Sjögren's syndrome or C4 levels in this context. *Can be associated with rheumatoid arthritis* - Sjögren's syndrome can be classified as **primary** (occurring alone) or **secondary** (occurring in conjunction with another autoimmune disease). - Its association with **rheumatoid arthritis** defines **secondary Sjögren's syndrome**, meaning it's not a characteristic feature of the *primary* form of the disease itself.
Question 1124: All the following are true about multiple myeloma except for which of the following?
- A. Hypercalcemia
- B. Presence of Bence-Jones proteins in urine
- C. Osteolytic bone disease
- D. Chromosomal translocation t(8;14), commonly seen in Burkitt's lymphoma (Correct Answer)
Explanation: ***t(8-14) translocation*** - The **t(8;14) translocation** is not typically associated with multiple myeloma; rather, it is commonly seen in **Burkitt lymphoma** [2]. - Multiple myeloma is primarily linked with chromosomal abnormalities such as **deletions** and **translocations involving different chromosomes**. *Osteolytic bone disease* - A hallmark feature of multiple myeloma, **osteolytic lesions** result from increased osteoclastic activity and are often seen in the skull, spine, and ribs [1]. - Patients frequently present with **bone pain** due to these lesions, which are characteristic of the disease [1]. *Light chain proliferation* - In multiple myeloma, a significant feature is the overproduction of **monoclonal light chains** [1]. - This leads to **light chain disease** or **renal impairment**, further supporting the diagnosis [1]. *Bence-Jones proteins in urine* - The presence of **Bence-Jones proteins**, which are free light chains, is a classic finding in multiple myeloma [1]. - They are often detected in the **urine** and can be used to monitor disease progression or response to treatment [1].
Question 1125: Which of the following is a characteristic feature of myasthenia gravis?
- A. Decreased levels of myosin in muscle fibers
- B. Absence of troponin C in muscle fibers
- C. Increased transmission at the myoneural junction
- D. Presence of antibodies against acetylcholine receptors (Correct Answer)
Explanation: ***Presence of antibodies against acetylcholine receptors*** - **Myasthenia gravis** is an **autoimmune disorder** characterized by the production of **antibodies against acetylcholine receptors** at the neuromuscular junction [1]. - These antibodies block, alter, or destroy the acetylcholine receptors, leading to impaired nerve-to-muscle communication and **muscle weakness** [2]. *Decreased levels of myosin in muscle fibers* - Myosin is a **motor protein** crucial for muscle contraction, and its decreased levels are not a primary feature of myasthenia gravis, but rather other **myopathies** or muscle wasting conditions. - The disease mechanism in myasthenia gravis is primarily at the **neuromuscular junction**, not within the muscle fibers themselves. *Absence of troponin C in muscle fibers* - **Troponin C** is a component of the troponin complex essential for **calcium-mediated muscle contraction**, found inside muscle fibers. - Its absence would lead to severe and widespread muscle dysfunction, unlike the specific and fluctuating weakness seen in **myasthenia gravis**. *Increased transmission at the myoneural junction* - Myasthenia gravis is characterized by **decreased** or **impaired transmission** at the myoneural (neuromuscular) junction due to the destruction or blockade of acetylcholine receptors [2]. - Increased transmission would lead to **muscle hyperactivity** or spasms, which is contrary to the **fatigable weakness** observed in myasthenia gravis.
Question 1126: Anomic aphasia is due to defect in
- A. Left inferior parietal lobe
- B. Left temporal lobe
- C. Temporal occipital lobe (Correct Answer)
- D. Cerebellum
Explanation: ***Temporal occipital lobe*** - Anomic aphasia, characterized by difficulty recalling **words or names (anomia)**, is most commonly associated with lesions in the **left temporo-occipital region**. - This area is crucial for **semantic processing** and word retrieval. *Left inferior parietal lobe* - Damage to the left inferior parietal lobe is more commonly associated with **conduction aphasia**, characterized by impaired repetition despite fluent speech and good comprehension. - It is also involved in aspects of **reading (alexia)** and **writing (agraphia)**. *Left temporal lobe* - While portions of the left temporal lobe (especially Wernicke's area) are critical for language comprehension, damage primarily to this area typically results in **Wernicke's aphasia**, where speech is fluent but meaningless, and comprehension is severely impaired. - Anomia can be a feature of Wernicke's aphasia, but the primary deficit is comprehension. *Cerebellum* - The cerebellum plays a significant role in **motor control**, balance, and coordination, but it is not directly involved in the **generation or comprehension of language** in the same way as cortical areas. - Damage to the cerebellum might lead to **dysarthria** (speech motor difficulties), but not typical aphasia.
Question 1127: What is the preferred test for confirming H. pylori eradication?
- A. Urease breath test (Correct Answer)
- B. Culture
- C. Serological test
- D. Biopsy urease test
Explanation: ***Urease breath test*** - The **urea breath test** is highly sensitive and specific for detecting active *H. pylori* infection and its eradication by measuring radioactive or non-radioactive labeled carbon dioxide released from metabolizing urea. - It is a non-invasive test preferred after treatment to confirm eradication, as it directly detects bacterial urease activity. *Culture* - **Culture** requires an invasive endoscopic biopsy, is expensive, and takes several days to yield results; therefore, it is not the preferred method for routine eradication confirmation. - While it offers the advantage of **antibiotic susceptibility testing**, its invasiveness and turnaround time make it less practical for post-treatment assessment. *Serological test* - **Serological tests** (blood tests for antibodies) remain positive for **H. pylori antibodies** for extended periods even after successful eradication, rendering them unsuitable for confirming eradication. - These tests primarily indicate past exposure rather than current, active infection. *Biopsy urease test* - A **biopsy urease test** involves an invasive endoscopy to obtain a tissue sample, which is then tested for urease activity. - Although useful for initial diagnosis, its invasiveness makes it less preferred for confirming eradication compared to the non-invasive breath test.
Physiology
1 questionsWhat is the primary mechanism underlying hyperthermia?
NEET-PG 2012 - Physiology NEET-PG Practice Questions and MCQs
Question 1121: What is the primary mechanism underlying hyperthermia?
- A. Temperature > 40°C with autonomic dysfunction
- B. Failure of thermoregulation (Correct Answer)
- C. Temperature > 41.5°C
- D. No change in hypothalamic set point
Explanation: ***Failure of thermoregulation*** - **Hyperthermia** is fundamentally caused by the body's inability to dissipate heat effectively, leading to an uncontrolled rise in core body temperature. - This differentiates it from fever, where the **hypothalamic set point** is elevated, and the body actively tries to reach that higher temperature. *Temperature > 41.5°C* - While a temperature exceeding **41.5°C** is often seen in severe hyperthermia, it is a *consequence* of the failure of thermoregulation, not its primary cause. - This extreme temperature indicates a critical state, but the underlying problem is the body's inability to control internal heat. *Temperature > 40°C with autonomic dysfunction* - A temperature above **40°C** combined with **autonomic dysfunction** (e.g., altered mental status, seizures) describes a severe *manifestation* of hyperthermia, often seen in heat stroke. - This is a symptom complex resulting from, rather than the primary cause of, the body's thermoregulatory failure. *No change in hypothalamic set point* - This statement is a *characteristic* of hyperthermia, distinguishing it from fever, where the **hypothalamic set point** is elevated. - However, the *absence* of this change is not the primary cause; rather, the underlying issue is the body's inability to manage its heat load despite a normal set point.
Psychiatry
1 questionsWhich of the following is NOT a characteristic of LEOPARD syndrome?
NEET-PG 2012 - Psychiatry NEET-PG Practice Questions and MCQs
Question 1121: Which of the following is NOT a characteristic of LEOPARD syndrome?
- A. Growth retardation
- B. ECG changes
- C. Hypertelorism
- D. Hypergonadism (Correct Answer)
- E. Lentigines
Explanation: ***Hypergonadism*** - **LEOPARD syndrome** is characterized by **hypogonadism** (underdevelopment or dysfunction of the gonads) and delayed puberty, not hypergonadism. - The acronym LEOPARD stands for multiple clinical features which include **L**entigines, **E**CG conduction abnormalities, **O**cular hypertelorism, **P**ulmonary stenosis, **A**bnormal genitalia, **R**etardation of growth, and **D**eafness. *Growth retardation* - **Retardation of growth** is a defining characteristic of LEOPARD syndrome, often manifesting as short stature. - This is part of the "R" in the LEOPARD acronym, indicating a failure to achieve normal growth milestones. *ECG changes* - **ECG conduction abnormalities** (such as prolonged PR interval, bundle branch block, or Wolff-Parkinson-White syndrome) are primary diagnostic features. - These cardiac issues can be significant and contribute to the morbidity associated with the syndrome. *Hypertelorism* - **Ocular hypertelorism**, meaning widely spaced eyes, is a common facial dysmorphism found in individuals with LEOPARD syndrome. - This feature is represented by the "O" in the LEOPARD acronym, along with other craniofacial anomalies. *Lentigines* - **Lentigines** are multiple pigmented macules (small, flat, darkened spots) that are the hallmark dermatologic feature of LEOPARD syndrome. - These represent the "L" in the LEOPARD acronym and are typically present from early childhood, increasing in number with age.