NEET-PG 2012 Practice Questions

Q: Which of the following is used for the diagnosis of asthma?

FEV1. ***FEV1*** - **Forced expiratory volume in 1 second (FEV1)** is the gold standard spirometric parameter for asthma diagnosis - Key diagnostic criteria include: - Reduced **FEV1/FVC ratio** (<0.70 or <0.75-0.80 in adults) - **Bronchodilator reversibility**: ≥12% and ≥200 mL increase in FEV1 after inhaled short-acting β2-agonist - This reversibility distinguishes asthma from fixed obstructive diseases like COPD - Serial **peak expiratory flow (PEF)** monitoring can also demonstrate variability characteristic of asthma *Measurement of tidal volume* - **Tidal volume** measures the amount of air inhaled or exhaled during normal breathing (typically ~500 mL at rest) - Not a diagnostic parameter for asthma as it doesn't assess **airway obstruction** or **hyperresponsiveness** - May be reduced during acute exacerbations but lacks specificity for asthma diagnosis *End expiratory flow rate* - Not a standard diagnostic parameter for asthma - While **mid-expiratory flow rates** (FEF25-75%) and **peak expiratory flow (PEF)** are assessed, **FEV1** remains the primary diagnostic measure - FEV1 provides better reproducibility and standardization for diagnosis *Total lung capacity* - **Total lung capacity (TLC)** represents total lung volume after maximal inhalation - May be normal or increased in asthma due to **air trapping** and hyperinflation - Not used as a primary diagnostic criterion as asthma diagnosis focuses on demonstrating **reversible airflow limitation**, not lung volumes

Q: In Marfan's syndrome, Aortic aneurysm occurs most commonly in:

Ascending aorta. ***Ascending aorta*** - The **ascending aorta** is the most common site for aortic aneurysm and dissection in Marfan syndrome due to cystic medial degeneration weakening the vessel wall [1]. - This predisposition is linked to defects in the **fibrillin-1 gene (FBN1)**, severely impacting the structural integrity of the arterial media primarily in the ascending aorta [1]. *Descending aorta* - While possible, **descending aortic** involvement is less common than ascending aortic involvement in Marfan syndrome [2]. - Aneurysms here are more frequently associated with atherosclerosis or other connective tissue disorders. *Abdominal aorta* - **Abdominal aortic aneurysms** are relatively rare in Marfan syndrome and are more typically seen in older patients with atherosclerosis [3]. - The disease primarily affects the elastic tissue content, which is most abundant in the proximal aorta. *Arch of aorta* - Aortic arch aneurysms can occur, but they are still less frequent than those in the **ascending aorta** as the primary initial site of dilation and dissection in Marfan syndrome. - Arch involvement often represents an extension of a more proximal ascending aortic pathology.

Q: Which structures are most commonly involved in a ciliary staphyloma?

Ciliary body and sclera. ***Ciliary body and sclera*** - A **staphyloma** is a localized bulging of the outer coat of the eye (sclera or cornea) lined internally by uveal tissue. - A **ciliary staphyloma** specifically involves the **ciliary body** and **sclera** at the region of the ciliary body, typically presenting as a dark bluish bulge at the limbal or perilimbal area. - This occurs due to weakening and ectasia of the sclera with prolapse of the underlying ciliary body, commonly seen following scleritis, perforating injuries, or surgeries. *Choroid and sclera* - This combination describes a **posterior staphyloma**, which occurs at the posterior pole of the eye, commonly seen in pathological myopia. - While medically accurate for posterior type, it does not describe a **ciliary staphyloma**. *Iris and sclera* - An **anterior staphyloma** primarily involves bulging of the **cornea** with incarceration of iris tissue, rather than sclera alone. - It occurs after corneal perforation with iris prolapse. *Cornea and conjunctiva* - This does not describe a staphyloma. Bulging of the cornea alone is termed **keratectasia** or **keratoconus**. - The **conjunctiva** is a superficial membrane and is not a structural component of staphyloma formation.

Q: What is the correct dose of i.v. adrenaline in term infants during neonatal resuscitation?

0.1-0.3 ml/kg in 1:10,000. ***0.1-0.3 ml/kg in 1:10,000*** - The recommended intravenous adrenaline dose for neonatal resuscitation is **0.01-0.03 mg/kg** using a **1:10,000 solution (0.1 mg/mL)**. - Volume calculation: 0.01-0.03 mg/kg ÷ 0.1 mg/mL = **0.1-0.3 mL/kg**. - This is the standard dose as per **NRP (Neonatal Resuscitation Program)** and **AHA guidelines** [2]. - The 1:10,000 concentration is safer for IV/umbilical venous catheter administration in neonates. *0.01-0.03 ml/kg in 1:1,000* - This volume is far too low for a 1:1,000 solution. - Would deliver only 0.01-0.03 mg total (not per kg), resulting in a **sub-therapeutic dose**. - The 1:1,000 concentration contains 1 mg/mL, which is **10 times more concentrated** than the recommended dilution. *0.3-0.5 ml/kg in 1:10,000* - This volume would deliver 0.03-0.05 mg/kg, which **exceeds the recommended maximum** of 0.03 mg/kg. - Higher doses can cause **severe adverse effects** including hypertension, arrhythmias, decreased myocardial function, and compromised coronary perfusion. - Not recommended as the standard initial dose. *0.03-0.05 ml/kg in 1:1,000* - The 1:1,000 concentration (1 mg/mL) is **too concentrated for IV use** in neonates [1]. - This volume would deliver 0.03-0.05 mg/kg from a highly concentrated solution, increasing risk of **severe cardiovascular complications**. - The 1:1,000 solution is reserved for **endotracheal administration** (at higher volumes of 0.5-1 mL/kg), not IV route.

Q: Rehydration therapy in a 2 year old severely dehydrated child is -

30 ml/kg in 30 min, 70 ml/kg in 2.5 hours. ***30 ml/kg in 30 min, 70 ml/kg in 2.5 hours*** - This option reflects the recommended rehydration protocol for a severely dehydrated child aged **12 months to 5 years**, where the first 30 ml/kg are given rapidly over 30 minutes, followed by 70 ml/kg over the next 2.5 hours. - This rapid initial infusion helps to quickly restore **circulating volume** and improve perfusion during severe dehydration. *30 ml/kg in 1 hour, 70 ml/kg in 5 hours* - This protocol is typically used for children with **some dehydration**, not severe dehydration, and is usually administered orally when possible. - The slower rate of rehydration would be insufficient for a severely dehydrated child requiring more urgent fluid replacement. *20 ml/kg in 30 min, 80 ml/kg in 2.5 hours* - While reflecting a rapid initial phase, the total volume and distribution of fluids differ from the WHO guidelines for **severe dehydration** in this age group. - The **initial 20 ml/kg over 30 minutes** is generally a slightly lower first bolus than recommended for very severe cases, and the subsequent phase is also adjusted. *75 ml/kg in 4 hours* - This represents a **lower total volume** (75 ml/kg compared to 100 ml/kg) and a different time distribution for severely dehydrated children in the 12 month to 5 year age group. - This protocol is more aligned with the management of **some dehydration** rather than the urgent requirements of severe dehydration.

Q: What does Pica refer to?

An appetite for non-nutritive substances. ***An appetite for non-nutritive substances*** - Pica is an eating disorder characterized by a persistent and compulsive craving for and consumption of **non-nutritive, non-food substances** for at least one month. - Common ingested substances include **dirt, clay, ice, hair, paint chips, and laundry starch**, often associated with **nutritional deficiencies** like iron deficiency anemia or **developmental disabilities**. *Ice sucking* - While **pagophagia (ice craving)** is a specific form of Pica, it represents only one manifestation and not the overarching definition of the disorder. - Isolated ice sucking can sometimes be a sign of **iron deficiency anemia**. *Thumb sucking* - **Thumb sucking** is a common habit, especially in infants and young children, typically associated with self-soothing and comfort. - It is not considered an eating disorder and does not involve the consumption of non-nutritive substances. *None of the options* - This option is incorrect because "An appetite for non-nutritive substances" accurately defines Pica.

Q: In a patient with acute cholecystitis, referred pain to the shoulder is known as

Boas' sign. ***Boas' sign*** - **Boas' sign** refers to the presence of hyperesthesia below the right scapula, which can also manifest as referred pain to the **right shoulder** or back [1]. - This symptom in acute cholecystitis is due to the **irritation** of the **phrenic nerve**, which shares sensory pathways with the shoulder region. *Murphy's sign* - **Murphy's sign** is elicited by asking the patient to exhale, then placing the examiner's hand below the costal margin on the right mid-clavicular line, and then asking the patient to inhale deeply [1]. - A positive sign is indicated by a sudden cessation of inspiration due to pain, which is specific for **acute cholecystitis** and not referred shoulder pain [1]. *Gray Turner sign* - The **Gray Turner sign** involves ecchymosis or discoloration of the flanks. - It is a severe indicator of **retroperitoneal hemorrhage**, often associated with acute pancreatitis, not cholecystitis [2]. *Cullen's sign* - **Cullen's sign** presents as periumbilical ecchymosis or discoloration around the navel. - This sign is also indicative of **retroperitoneal hemorrhage**, typically seen in serious conditions like ruptured ectopic pregnancy or acute pancreatitis.

Q: Circumcision is contraindicated in

Hypospadias. ***Hypospadias*** - In **hypospadias**, the **urethral opening** is located on the underside of the penis, and the foreskin is **essential** for **reconstructive surgery** (urethroplasty) to correct the defect. - Removing the foreskin via circumcision would eliminate this vital tissue, making surgical repair extremely difficult or impossible. - This is the **most absolute contraindication** to circumcision in pediatric urology. *Balanitis* - **Balanitis** is inflammation of the glans penis, often due to poor hygiene or infection. - Circumcision is actually a **treatment** for recurrent balanitis, not a contraindication. - It represents an **indication** for circumcision, not a contraindication. *Paraphimosis* - **Paraphimosis** is a urological emergency where the retracted foreskin becomes trapped behind the glans, causing vascular compromise. - Immediate management involves manual reduction or dorsal slit procedure. - Once the acute condition is resolved, elective circumcision can be performed to prevent recurrence—**not a contraindication**. *Exstrophy of bladder* - **Bladder exstrophy** is a severe congenital anomaly involving the epispadias-exstrophy complex, where the bladder is exposed outside the body. - The foreskin is typically **preserved for penile reconstruction** during complex staged repairs. - While this is also considered a **contraindication to circumcision** in most cases, **hypospadias** remains the **classic and most absolute contraindication** taught in medical education and is the expected answer for this question.

Q: What does the term 'gastrotomy' refer to?

Making an incision into the stomach. ***Making an incision into the stomach*** - The suffix **-otomy** specifically refers to the **surgical creation of an incision** or a cutting open of an organ or structure. - In this context, **gastr-** refers to the **stomach**, thus "gastrotomy" means cutting into the stomach. *Closing the stomach after tube insertion* - While a gastrotomy might precede tube insertion, "closing" the stomach is distinct and typically part of the **wound closure** rather than the incision itself. - The term for surgical closure is generally **-rrhaphy**, not -otomy. *Removing a part of the stomach* - The surgical removal of a part of an organ is indicated by the suffix **-ectomy**, such as in **gastrectomy**. - Gastrotomy only implies making an incision, not the resection of tissue. *Resecting the upper part of the stomach* - This describes a **partial gastrectomy** or **fundectomy**, which involves the removal of tissue. - Gastrotomy is a simpler procedure involving only an incision, without tissue removal.

Question 1

Which of the following is used for the diagnosis of asthma?

Accepted Answer

FEV1

Answer

Measurement of tidal volume

Answer

End expiratory flow rate

Answer

Total lung capacity

Question 2

In Marfan's syndrome, Aortic aneurysm occurs most commonly in:

Accepted Answer

Ascending aorta

Answer

Descending aorta

Answer

Abdominal aorta

Answer

Arch of aorta

Question 3

What is a feature of short bowel syndrome?

Accepted Answer

Malabsorption leading to diarrhea, dehydration, and malnutrition.

Answer

Hypergastrinemia & high gastric secretion is seen

Answer

Diarrhea, dehydration and malnutrition

Answer

Chronic TPN dependence

Question 4

Which structures are most commonly involved in a ciliary staphyloma?

Accepted Answer

Ciliary body and sclera

Answer

Choroid and sclera

Answer

Cornea and conjunctiva

Answer

Iris and sclera

Question 5

What is the correct dose of i.v. adrenaline in term infants during neonatal resuscitation?

Accepted Answer

0.1-0.3 ml/kg in 1:10,000

Answer

0.03-0.05 ml/kg in 1:1,000

Answer

0.01-0.03 ml/kg in 1:1,000

Answer

0.3-0.5 ml/kg in 1:10,000

Question 6

Rehydration therapy in a 2 year old severely dehydrated child is -

Accepted Answer

30 ml/kg in 30 min, 70 ml/kg in 2.5 hours

Answer

75 ml/kg in 4 hours

Answer

30 ml/kg in 1 hour, 70 ml/kg in 5 hours

Answer

20 ml/kg in 30 min, 80 ml/kg in 2.5 hours

Question 7

What does Pica refer to?

Accepted Answer

An appetite for non-nutritive substances

Answer

Ice sucking

Answer

Thumb sucking

Answer

None of the options

Question 8

In a patient with acute cholecystitis, referred pain to the shoulder is known as

Accepted Answer

Boas' sign

Answer

Murphy's sign

Answer

Gray Turner sign

Answer

Cullen's sign

Question 9

Circumcision is contraindicated in

Accepted Answer

Hypospadias

Answer

Paraphimosis

Answer

Exostrophy of bladder

Answer

Balanitis

Question 10

What does the term 'gastrotomy' refer to?

Accepted Answer

Making an incision into the stomach

Answer

Closing the stomach after tube insertion

Answer

Removing a part of the stomach

Answer

Resecting the upper part of the stomach

NEET-PG 2012

Internal Medicine

Ophthalmology

Pediatrics

Psychiatry

Surgery