Antibiotics — Flashcards

Flashcard 931: Proteasomal inhibitors work best in cancers that mark _____ proteins to be targeted for degradation too quickly

Answer: pro-apoptotic

Flashcard 932: What is the most common adverse effect of Clindamycin?_____

Answer: Diarrhea

Flashcard 933: _____ is a macrolide antibiotic that can be used to treat diptheria caused by Corynebacterium diphtheriae.

Answer: Erythromycin

Flashcard 934: _____ may increase the serum concentration of theophylline or oral anticoagulants

Answer: Macrolides

Flashcard 935: _____ is an antibiotic that is avoided in pregnancy as it causes "Gray Baby" Syndrome.

Answer: Chloramphenicol

Flashcard 936: Red man syndrome is characterized by histamine release with possible _____-tension

Answer: hypo

Flashcard 937: Which step of bacterial protein synthesis does Chloramphenicol inhibit?

Answer: Peptidyl transferase (50S subunit)

Extra: Chloramphenicol binds to the 50S ribosomal subunit and inhibits the peptidyl transferase enzyme, preventing peptide bond formation. It is generally bacteriostatic.

Flashcard 938: What is the treatment for Nocardia spp. infection?_____

Answer: Sulfonamides

Flashcard 939: What is the first-line treatment of complicated UTIs?_____

Answer: Fluoroquinolones

Flashcard 940: Which class of drugs can displace warfarin (and other drugs) from serum albumin?_____

Answer: Sulfonamides