Oxazolidinones and streptogramins US Medical PG Flashcards - Medical Study Cards
Master Oxazolidinones and streptogramins with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Oxazolidinones and streptogramins Flashcard Deck - 10 Cards
Flashcard 1: Quinupristin-dalfopristin bind to the _____ ribosomal subunit
Answer: 50S
Flashcard 2: What is the mechanism of action of the Streptogramin combination **Quinupristin-Dalfopristin**?
Answer: Inhibits bacterial protein synthesis by binding to the **50S subunit**:
1. **Dalfopristin**: Inhibits peptidyl transferase (peptide bond formation)
2. **Quinupristin**: Inhibits translocation (peptide exit)
Extra: Individually they are bacteriostatic, but the combination is bactericidal. Used for VRE (*E. faecium*) and MRSA.
Flashcard 3: What lipopeptide can be used to treat VRE (vancomycin resistant enterococcus)?_____
Answer: Daptomycin
Flashcard 4: Which antibiotic can precipitate serotonin toxicity when coadministered with SSRIs, SNRIs, MAOIs, and bupropion?
Answer: Linezolid
Flashcard 5: Which bacterial protein synthesis inhibitor can cause thrombocytopenia (beside chloramphenicol)?_____
Answer: Linezolid
Flashcard 6: What antibiotic can increase risk for serotonin syndrome? _____
Answer: Linezolid
Flashcard 7: Which protein synthesis inhibitor can precipitate serotonin syndrome?_____
Answer: Linezolid
Flashcard 8: β-lactam antibiotics inhibit what family of enzymes involved in cell wall synthesis?
_____
Answer: Penicillin binding protein transpeptidases
Extra:
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Flashcard 9: _____-toxicity is associated with Isoniazid use
Answer: Hepato
Extra:
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Flashcard 10: Clavulanic acid (clavulanate) is a suicide β-lactamase inhibitor that is combined with the aminopenicillin _____ (Augmentin) or the antipseudomonal _____
Answer: amoxicillin
Extra:
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