Antibiotics — Flashcards

Flashcard 581: Cephalosporins: susceptibility to β-lactamases (penicillinases)

Answer: Relatively resistant (less susceptible than penicillins)

Extra: Cephalosporins are β-lactam antibiotics that are structurally more resistant to many β-lactamases (specifically penicillinases) compared to penicillins. However, they are still susceptible to specific enzymes like cephalosporinases and extended-spectrum β-lactamases (ESBLs).

Flashcard 582: _____ is an aminopenicillin that can be used to treat (non-vancomycin resistant) Enterococcus infection (E. faecalis, E. faecium).

Answer: Ampicillin

Flashcard 583: Vancomycin is bacterio-_____

Answer: cidal

Flashcard 584: Trimethoprim can produce what teratogenic defects?_____

Answer: Neural tube defects

Flashcard 585: Which bacterial ribosomal subunit is targeted by Chloramphenicol?_____

Answer: 50S

Flashcard 586: Aminoglycosides are actively transported into the cell via an _____-dependent process

Answer: oxygen

Flashcard 587: Linezolid is bacterio-_____

Answer: static**

Flashcard 588: Which antibiotic blocks peptidyltransferase at the 50S subunit?_____

Answer: Chloramphenicol

Flashcard 589: What cephalosporin can bind the altered PBPs of MRSA? _____

Answer: Ceftaroline

Flashcard 590: Which 3rd generation cephalosporin can treat Pseudomonas aeruginosa infection?_____

Answer: Ceftazidime