Lipid metabolism — Flashcards

Anorexia = _____cholesterolemia

_____ Cholesterol or _____ bile salts = ↑ risk of gallstones

Characteristics of _____: Hepatosplenomegaly Pancytopenia Bone pain/fractures Failure to thrive and delayed puberty

Hint: genetic condition

What is the normal range of Triglycerides, serum?

What is the normal range of Cholesterol, serum (Recommendation)?

A 12 y/o girl is involved in a motor vehicle accident. - Abdominal CT is negative for traumatic injury. - She is incidentally found to have an abnormal intra-abdominal mass. - Biopsy of mass reveals ectopic tissue. - On microscopy, these cells have a highly developed smooth endoplasmic reticulum. - These cells most likely receive stimulation from which of the following agents? a. Parathyroid hormone b. Progesterone c. ACTH d. Aldosterone e. Dopamine

Cultured fibroblast taken from an infant suffering from hypotonia & seizures. -It shows an impaired ability to oxidize very long chain fatty acids (VLCFA) & Phytanic acid. -The defect most likely localized to:

What are the followings defects in relation to hyperlipoproteinemias -ApoC-2 production -Cholesterol esterification in the blood -Chylomicron remnant uptake by liver cells -LDL particle uptake by hepatocytes -Lipoprotein lipase activity

3 y/o patient presents with cherry-red spots and loss of motor skills. - Physical exam: No splenomegaly - What is the most likely enzyme deficiency that causes this disease?

Accumulation of the following presents with what disease? - Cerebroside sulfate - Galactocerebroside - Globotriaosylceramide - Glucocerebroside - GM2 ganglioside - Sphingomyelin