Lipid metabolism — Flashcards

Flashcard 11: apolipoprotein E

Answer:

Extra: mediates remnant uptake

Flashcard 12: apolipoprotein A-I

Answer:

Extra: activates LCAT

Flashcard 13: apolipoprotein C-II

Answer:

Extra: lipoprotein lipase cofactor

Flashcard 14: apolipoprotein B-48

Answer:

Extra: mediates chylomicron secretion

Flashcard 15: apolipoprotein B-100

Answer:

Extra: binds LDL receptor

Flashcard 16: In general, what is the composition of lipoproteins?

Answer: cholesterol, triglycerides, phospholipids

Flashcard 17: Give the life cycle of a chylomicron.

Answer: created by intestine, delivers dietary TGs to tissues and cholesterol to liver

Flashcard 18: Give the life cycle of VLDL.

Answer: created by liver, delivers hepatic TGs to peripheral tissues

Flashcard 19: Give the life cycle of IDL.

Answer: formed by degradation of VLDL in peripheral tissues, delivers TGs and cholesterol back to liver

Flashcard 20: abetalipoproteinemia

Answer:

Extra: low chylomicron and VLDL synthesisfailure to thrive, steatorrhea, ataxia, night blindnessacanthocytes, lipid accumulation within enterocytesARmicrosomal triglyceride transfer protein