Drugs for Gastrointestinal Diseases — Flashcards
On this page
Bile acid resins can lead to _____, which may impair the absorption of fat-soluble vitamins (A, D, E, K)
_____ is a gastroprokinetic agent which acts as a 5-HT4 receptor agonist
_____ is CCK-B receptor antagonist used in treatment of gastrinoma/Zollinger-Ellison Syndrome
Treatment of IBD (Crohn's, UC) may involve immunosuppressors, such as _____ and 6-mercaptopurine
GI (Anti-Emetics; 'Vomitorium')_____ antagonizes D2 receptors in the area postrema (treats chemotherapy induced vomiting)
_____ is made of two molecules of 5-ASA used in the treatment of Inflammatory Bowel Disease
_____ (macrolide) can bind GI motilin receptors, increasing GI motility and causing diarrhea
Because PGE1 is involved in physiological responses of the gut mucosa and the uterine smooth muscle, Misoprostol can cause _____ as well as uterine contractions
Cholestatic DrugsObeticholic Acid is a semisynthetic _____ used to treat Primary Biliary Cholangitis
Anti-Emetics; "Vomitorium"_____ antagonizes NK1 receptors in the area postrema, which is used to treat chemotherapy-induced vomiting
Drugs for Gastrointestinal Diseases Indian Medical PG Flashcards - Medical Study Cards
Master Drugs for Gastrointestinal Diseases with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Drugs for Gastrointestinal Diseases Flashcard Deck - 77 Cards
Flashcard 1: Bile acid resins can lead to _____, which may impair the absorption of fat-soluble vitamins (A, D, E, K)
Answer: steatorrhea
Flashcard 2: _____ is a gastroprokinetic agent which acts as a 5-HT4 receptor agonist
Answer: Cisapride
Flashcard 3: _____ is CCK-B receptor antagonist used in treatment of gastrinoma/Zollinger-Ellison Syndrome
Answer: Netazepide
Flashcard 4: Treatment of IBD (Crohn's, UC) may involve immunosuppressors, such as _____ and 6-mercaptopurine
Answer: azathioprine
Flashcard 5: GI (Anti-Emetics; 'Vomitorium')_____ antagonizes D2 receptors in the area postrema (treats chemotherapy induced vomiting)
Answer: Metoclopramide
Flashcard 6: _____ is made of two molecules of 5-ASA used in the treatment of Inflammatory Bowel Disease
Answer: Olsalazine
Flashcard 7: _____ (macrolide) can bind GI motilin receptors, increasing GI motility and causing diarrhea
Answer: Erythromycin
Flashcard 8: Because PGE1 is involved in physiological responses of the gut mucosa and the uterine smooth muscle, Misoprostol can cause _____ as well as uterine contractions
Answer: diarrhea
Flashcard 9: Cholestatic DrugsObeticholic Acid is a semisynthetic _____ used to treat Primary Biliary Cholangitis
Answer: bile acid
Flashcard 10: Anti-Emetics; "Vomitorium"_____ antagonizes NK1 receptors in the area postrema, which is used to treat chemotherapy-induced vomiting
Answer: Aprepitant
Flashcard 11: When proton pump inhibitors are unable to control gastric acid secretion, _____ (a long acting somatostatin analog) may be of use in treating gastrinomas
Answer: octreotide
Flashcard 12: Anti-Emetics; 'Vomitorium'_____ antagonizes the 5-HT3 receptor on vagal afferents in the GI tract
Answer: Ondansetron
Flashcard 13: Bile acid resins frequently cause GI side effects, such as _____ and bloating
Answer: constipation
Flashcard 14: H2 receptor antagonists are especially effective at reducing _____ secretion of acid, however, they only have modest impact on meal-stimulated secretion of acid
Answer: nocturnal
Flashcard 15: In the treatment of Cystic Fibrosis, Creon (pancrelipase) is a mix of _____ enzymes used to restore pancreatic function
Answer: pancreatic
Flashcard 16: GI (Relaxatives)_____ is a -opioid agonist that does cross the BBB, therefore it is combined with atropine to prevent abuse
Answer: Diphenoxylate
Flashcard 17: A major adverse effect of orlistat is _____, which may lead to decreased absorption of fat-soluble vitamins
Answer: steatorrhea
Flashcard 18: Histamine, from ECL cells, activates _____ receptors (coupled to Gs) on the basolateral membrane of parietal cells
Answer: H2
Flashcard 19: GI_____ is a non-toxic bile acid used in the treatment of early primary biliary cirrhosis
Answer: Ursodeoxycholic acid (ursodiol)
Flashcard 20: Loperamide is a _____ agonist that does not cross the BBB, therefore there is no analgesia and low potential for addiction
Answer: Loperamide
Flashcard 21: Guanylcycline C agonist indicated in _____ constipation is linaclotide.
Answer: chronic
Flashcard 22: Chronic use of _____ causes brown pigmentation of the colon, known as melanosis coli
Answer: senna
Flashcard 23: Mesalamine (5ASA) works by inhibiting the synthesis of proinflammatory _____ and cytokines
Answer: eicosanoids
Flashcard 24: GI _____ is a PGE1 analog that may be used to prevent NSAID-induced peptic ulcers
Answer: Misoprostol
Flashcard 25: Polymerization of _____ occurs only at an acidic pH by crosslinking of the molecules, which helps in gastic ulcer protection
Answer: sucralfate
Flashcard 26: Sulfasalazine is metabolized by _____ into the active component (mesalamine) which is used to treat the colitis aspects of IBD
Answer: colonic Bacteria
Flashcard 27: Cholestatic DrugsUrsodeoxycholic Acid is a synthetic secondary bile acid used primarily for patients with _____ gall stones that have contraindications to surgery
Answer: chronic
Flashcard 28: _____ is indicated with pyridoxine to reduce mild to moderate nausea and vomiting in the early stages of pregnancy
Answer: Doxylamine
Flashcard 29: Ondansetron is used to treat _____ or post-operative induced nausea and vomiting
Answer: chemotherapy
Flashcard 30: Misoprostol can be clinically used to treat gastric ulcers as at _____ doses it inhibits secretion of gastric acid
Answer: high
Flashcard 31: Metoclopramide has upper GI prokinetic effects, making it useful for treatment of _____ due to post-surgical disorders and diabetic gastroparesis
Answer: delayed gastric emptying
Flashcard 32: _____ is made of 5-ASA and an inert compound used in the treatment of Inflammatory Bowel Disease
Answer: Balsalazide
Flashcard 33: _____ agonism (-pride) and D2 antagonism can result in prokinetic action by increasing the cholinergic activity of the gut.
Answer: 5HT4
Flashcard 34: Treatment of IBD (Crohn's, UC) may involve TNF- inhibitors, such as _____ and adalimumab
Answer: infliximab
Flashcard 35: Gastroesophageal Refund _____ receptor antagonists (e.g. cimetidine) may be used to treat GERD and peptic ulcers, although PPIs are the first line treatment
Answer: H2
Flashcard 36: First Aid Pharmacology: GI (Weight Loss)_____ is an inhibitor of gastric and pancreatic lipase, thus leading to decreased breakdown and absorption of dietary fats
Answer: Orlistat
Flashcard 37: Alpha-glucosidase inhibitors (e.g. acarbose, miglitol) are infrequently prescribed due to their ability to cause _____, flatulence, and abdominal pain as side effects
Answer: diarrhea
Flashcard 38: Sucralfate is a basic _____ salt of sucrose sulfate
Answer: aluminum
Flashcard 39: GI (Anti-Emetics; "Vomitorium")_____ is a muscarinic (M1) antagonist that treats vestibular nausea (motion sickness)
Answer: Scopolamine
Flashcard 40: Two main side effects of osmotic laxatives include _____ and dehydration
Answer: diarrhea
Flashcard 41: Proton pump inhibitors (PPIs) _____ inhibit the H+/K+-ATPase pump, which is the final common pathway for H+ secretion
Answer: irreversibly
Flashcard 42: _____ is a surfactant that decreases foaming and is included in many antacid preparations to reduce gastroesophageal reflux.
Answer: Simethicone
Flashcard 43: Ursodeoxycholic acid acts via increasing _____ secretion and decreasing cholesterol secretion/reabsorption
Answer: bile
Flashcard 44: _____ is a GLP-2 analogue
Answer: Teduglutide
Flashcard 45: _____ acts by inhibiting the cAMP-stimulated CFTR chloride channel and calcium-activated chloride channels on the luminal side of intestine.
Answer: Crofelemer
Flashcard 46: Misoprostol promotes increased production and secretion of a gastric _____ barrier and decreased acid production
Answer: mucous
Flashcard 47: First Aid Pharmacology: GI_____ is a combination drug that may be used to treat ulcerative colitis and Crohn disease (colitis component)
Answer: Sulfasalazine
Flashcard 48: _____ is the oral PPI preparation that causes fastest acid suppression
Answer: Rabeprazole
Flashcard 49: Gastric bezoars are commonly associated with antacids such as _____.
Answer: sucralfate
Flashcard 50: _____ is approved for treatment of short-bowel syndrome
Answer: Teduglutide (GLP-2 analogue)
Flashcard 51: Which H2 antagonist also has a nitric oxide releasing property?_____
Answer: Lafutidine
Flashcard 52: _____ is a cytoprotective agent used in the treatment of gastric ulcers*mechanism of action?
Answer: Rebamipide
Flashcard 53: Proton-pump inhibitors are most effective when they are given _____
Answer: before meals
Flashcard 54: _____ is indicated for non-infectious diarrhea associated with antiretroviral therapy in HIV/AIDS.
Answer: Crofelemer
Flashcard 55: Which drug is approved for resistant diarrhea-predominant irritable bowel syndrome in female patients?_____
Answer: Alosetron
Flashcard 56: Vedolizumab is an anti-_____ monoclona antibody that is used in the treatment of Crohn's disease and Ulcerative Colitis
Answer: 47 integrin
Flashcard 57: Which antibiotic is used for diarrhea-predominant IBS?_____
Answer: Rifaximin
Flashcard 58: _____ is a selective M1 anticholinergic drug used for decreasing Gastric acid secretions in Peptic Ulcer
Answer: Pirenzepine
Flashcard 59: _____ is indicated for the reversal of opioid-induced constipation in patients on chronic opioid therapy.
Answer: Methylnaltrexone
Flashcard 60: _____ is a peripheral enkephalinase inhibitor.
Answer: Racecadotril
Flashcard 61: The most effective therapy for NSAID-induced ulcer is _____
Answer: proton pump inhibitors.
Flashcard 62: Which local anesthetic is commonly used for symptomatic relief of gastritis?_____
Answer: Oxethazaine
Flashcard 63: The 5HT3 antagonist having maximum potency in chemotherapy-induced vomiting is _____.
Answer: palonosetron
Flashcard 64: Which drug is preferred for chronic idiopathic constipation and constipation-predominant irritable bowel syndrome?_____
Answer: Lubiprostone
Flashcard 65: _____ is a peripherally acting opioid antagonist used for the treatment of constipation in morphine administration
Answer: Naloxegol
Flashcard 66: _____ is a prokinetic agent that can cause QT interval prolongation
Answer: Cisapride
Flashcard 67: PPIs should be ideally given _____ minutes before breakfast.
Answer: 30
Flashcard 68: Triple therapy for H-Pylori infection:[PPI + Clarithromycin _____ mg + Amoxicillin _____g] * BD for 10-14 daysMetronidazole 500 mg BD can be substituted for Amoxicillin
Answer: 500; 1
Flashcard 69: Ondansetron can _____ suppress vomiting caused by motion sickness.
Answer: not
Flashcard 70: _____ is an opioid drug approved for the treatment of diarrhea-predominant irritable bowel syndrome(IBS)
Answer: Eluxadoline
Flashcard 71: Drug of choice for Zollinger Ellison syndrome:
Answer: Omeprazole
Flashcard 72: Drug of choice for prevention of NSAID induced peptic ulcer disease is
Answer: Proton Pump Inhibitors (PPIs)
Flashcard 73: Drug of choice for the following condition is (endoscopic view)
Answer: Ketoconazole
Flashcard 74: Drug of choice for diabetic diarrhea:
Answer: Duloxetine
Flashcard 75: Drug of choice for chronic use NSAID induced peptic ulcer:
Answer: Misoprostol
Flashcard 76: Drug of choice for Wilson's disease with hepatic compensation?
Answer: Zinc
Flashcard 77: Drug of choice for late cisplatin induced vomiting is
Answer: Palonosetron
Keywords: Drugs for Gastrointestinal Diseases flashcards, medical flashcards, NEET PG preparation, USMLE Step 1 flashcards, Anki alternative, spaced repetition medical, OnCourse flashcards
Study by Chapter
Acid-Peptic Disease Therapeutics
Flashcards
Proton Pump Inhibitors
Flashcards
H2 Receptor Antagonists
Flashcards
Antacids and Mucosal Protectants
Flashcards
Antiemetics
Flashcards
Prokinetic Agents
Flashcards
Laxatives and Purging Agents
Flashcards
Antidiarrheal Drugs
Flashcards
Drugs for Inflammatory Bowel Disease
Flashcards
Pancreatic Enzyme Supplements
Flashcards
Want unlimited flashcards?
Get full access to all flashcards, spaced repetition, and progress tracking.
Start For Free