Drugs Affecting Blood and Blood Formation — Flashcards

Flashcard 31: _____ is a preformed complex of plasminogen and streptokinase.

Answer: Anistreplase

Flashcard 32: First Aid Pharmacology: Respiratory Epoprostenol and iloprost _____ platelet aggregation

Answer: inhibit

Flashcard 33: _____ to heparin shows therapeutic anti-factor Xa levels with a subtherapeutic aPTT. (therapeutic/subtherapeutic)

Answer: Pseudo-resistance

Flashcard 34: _____ to heparin shows subtherapeutic anti-factor Xa levels with a subtherapeutic aPTT. (therapeutic/subtherapeutic)

Answer: Resistance

Flashcard 35: PDE inhibitors (e.g. cilostazol, dipyridamole) _____ cAMP, which inhibits platelet aggregation

Answer: increase

Flashcard 36: _____ is an anticoagulant that interferes with the gamma-carboxylation of vitamin K-dependent clotting factors (II, VII, IX, X).

Answer: Warfarin

Extra: Warfarin inhibits vitamin K epoxide reductase (VKORC1), preventing the regeneration of reduced vitamin K. Reduced vitamin K is a cofactor for the enzyme gamma-glutamyl carboxylase, which carboxylates factors II, VII, IX, X, and proteins C and S.

Flashcard 37: The anti-coagulants _____ and S are reduced early in warfarin therapy, leading to a hyper-coaguable state

Answer: protein C

Flashcard 38: Fibrates significantly decrease serum _____ by increasing hydrolysis of VLDLs and chylomicrons

Answer: triglycerides

Flashcard 39: Prostaglandin _____ causes decreased platelet aggregation

Answer: I2 (prostacyclin)

Flashcard 40: _____ receptors (PAR-1), are activated by thrombin and contributes to platelet aggregation

Answer: Protease activated