Thrombolytic Agents — Flashcards

Flashcard 1: Which thrombin-like enzyme is used to differentiate the effect of heparin from afibrinogenemia?

Answer: Reptilase

Extra: Reptilase (from *Bothrops atrox* venom) is a thrombin-like enzyme that converts fibrinogen to fibrin but is **not** inhibited by the heparin-antithrombin III complex. - **Heparin presence:** Prolonged Thrombin Time (TT), Normal Reptilase Time (RT). - **Afibrinogenemia/Dysfibrinogenemia:** Both Thrombin Time and Reptilase Time are prolonged.

Flashcard 2: Thrombolytics result in an _____ PT and elevated PTT

Answer: elevated

Flashcard 3: Which r-tPA (fibrinolytic) has the shortest half life?_____

Answer: Alteplase

Flashcard 4: _____ is a preformed complex of plasminogen and streptokinase.

Answer: Anistreplase

Flashcard 5: Treatment for disorders of fibrinolysis is _____, which blocks activation of plasminogen

Answer: aminocaproic acid

Flashcard 6: _____ are indicated for the emergency reversal of warfarin therapy in uncontrolled hemorrhage

Answer: Prothrombin Complex Concentrates

Flashcard 7: Which oral thrombin inhibitor is contraindicated in patients with mechanical heart valves?_____

Answer: Dabigatran

Flashcard 8: _____ is considered superior to all other parenteral iron supplementation especially for postpartum IDA.

Answer: Ferric carboxymaltose

Flashcard 9: Treatment of hemophilia A involves _____ plus recombinant factor VIII

Answer: desmopressin

Flashcard 10: _____ is a competitive antagonist of PAR-1

Answer: Vorapaxar