Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 381: _____ is OHA which causes lactic acidosis in impaired renal function

Answer: Metformin

Flashcard 382: _____ and doxazosin are drugs used in BPH that promote prostatic apoptosis

Answer: Terazosin

Flashcard 383: Livedo reticularis is a side effect of _____

Answer: amantadine

Flashcard 384: _____ solutions are preferred over _____ for KCL administration for management of hypokalemia

Answer: Saline; Dextrose

Flashcard 385: _____ has been FDA-approved for the treatment of neuromyelitis optica (NMO).

Answer: Eculizumab

Flashcard 386: Sugammadex is a selective relaxant binding agent used to reverse the effects of which class of neuromuscular blockers?

Answer: Aminosteroids (specifically Rocuronium and Vecuronium)

Extra: Sugammadex works by encapsulating (chelating) the drug molecules in a 1:1 ratio. **It is effective against:** * Aminosteroids (Rocuronium > Vecuronium >> Pancuronium) **It is NOT effective against:** * Benzylisoquinolines (e.g., Atracurium, Cisatracurium, Mivacurium) * Depolarizing agents (Succinylcholine)

Flashcard 387: _____ poisoning causes PCT damage with proteinuria and muscle pain.

Answer: Bismuth

Flashcard 388: _____ is recommended for reconstituting the BCG vaccine

Answer: Normal saline

Flashcard 389: Raloxifene _____ the incidence of venous thrombosis

Answer: increases

Flashcard 390: A patient with theophylline poisoning developed hypotension. Drug of choice in theophylline poisoning with hypotension is:

Answer: Vasopressors (e.g., norepinephrine)