Drug-Induced QT Prolongation — Flashcards

Flashcard 1: Type _____ adverse drug reactions are based on the pharmacological properties of the drug

Answer: A (augmented)

Flashcard 2: _____ poisoning causes PCT damage with proteinuria and muscle pain.

Answer: Bismuth

Flashcard 3: Why is physostigmine not recommended in management of TCA toxicity?_____

Answer: can aggravate cardiac depression and cause seizures

Flashcard 4: _____ used as an antidote for arsenic poisoning blocks complex _____ of the electron transport chain.

Answer: BAL(British anti-lewisite); III

Flashcard 5: What finding correlates with the severity and mortality in severe OP poisoning?_____

Answer: Prolonged QTc interval

Flashcard 6: Livedo reticularis is a side effect of _____

Answer: amantadine

Flashcard 7: Drugs with a _____ therapeutic index require therapeutic drug monitoring (TDM).

Answer: narrow

Extra: Mnemonic for Narrow Therapeutic Index (NTI) drugs: **W**atch **T**he **D**rug **L**evels **P**lease **A**lways (**W**arfarin, **T**heophylline, **D**igoxin, **L**ithium, **P**henytoin, **A**minoglycosides).

Flashcard 8: Classification of Adverse drug reactions (ADRs): - Type A: _____ - Type B: Bizarre - Type C: Chronic - Type D: Delayed - Type E: End of use - Type F: Failure

Answer: Augmented

Flashcard 9: Which group of modified penicillins is especially associated with Acute Interstitial Nephritis (AIN)? _____

Answer: Dicloxacillin, Nafcillin, Oxacillin

Flashcard 10: If a patient taking penicillin manifests with mild fever, myalgia or arthralagias, and the following rash, they are demonstrating what side effect? _____

Answer: Hypersensitivity Vasculitis (Cutaneous Small Vessel Vasculitis)