Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 371: _____ is OHA which causes lactic acidosis in impaired renal function

Answer: Metformin

Flashcard 372: _____ enzyme activity is the most accurate indicator to assess potential Organophosphate toxicity.

Answer: RBC cholinesterase

Flashcard 373: _____ of the urine is useful in the management of amphetamine toxicity.

Answer: Acidification::Acidification/Alkalinisation

Flashcard 374: _____ used as an antidote for arsenic poisoning blocks complex _____ of the electron transport chain.

Answer: BAL(British anti-lewisite); III

Flashcard 375: Sugammadex is a selective relaxant binding agent used to reverse the effects of which class of neuromuscular blockers?

Answer: Aminosteroids (specifically Rocuronium and Vecuronium)

Extra: Sugammadex works by encapsulating (chelating) the drug molecules in a 1:1 ratio. **It is effective against:** * Aminosteroids (Rocuronium > Vecuronium >> Pancuronium) **It is NOT effective against:** * Benzylisoquinolines (e.g., Atracurium, Cisatracurium, Mivacurium) * Depolarizing agents (Succinylcholine)

Flashcard 376: _____ has been FDA-approved for the treatment of neuromyelitis optica (NMO).

Answer: Eculizumab

Flashcard 377: _____ poisoning causes PCT damage with proteinuria and muscle pain.

Answer: Bismuth

Flashcard 378: Among the **oral** forms of nicotine replacement therapy (NRT), nicotine _____ offer the highest level of nicotine delivery.

Answer: lozenges

Flashcard 379: Excess of _____ causes alkali disease in livestock.

Answer: selenium

Flashcard 380: _____ is a cardiotoxic drug that causes myocardial stunning and LV dysfunction, without myocyte damage

Answer: Trastuzumab