Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 291: Which anti-hypertensive drugs are associated with exacerbation of psoriasis?

Answer: Beta-blockers, ACE inhibitors (ACEIs), and ARBs

Flashcard 292: Which poisoning results in a **left shift** of the oxygen-hemoglobin dissociation curve and a **decreased oxygen-carrying capacity**?

Answer: Carbon monoxide poisoning

Flashcard 293: _____ toxicity can cause bull s eye maculopathy.

Answer: Hydroxychloroquine

Flashcard 294: Cicuta maculata (water hemlock) is a ____

Answer: Convulsant (GABA-A antagonist)

Flashcard 295: Is 2-naphthylamine a direct or indirect acting carcinogen?

Answer: Indirectly acting carcinogen (procarcinogen)

Extra: 2-naphthylamine is a procarcinogen classically associated with bladder cancer (urothelial carcinoma). It requires metabolic activation (specifically N-hydroxylation in the liver) to form its active carcinogenic metabolite.

Flashcard 296: Cardiotoxicity due to bupivacaine usually manifests as cardiovascular _____

Answer: depression

Flashcard 297: In nephrotic syndrome, the effect of Warfarin is _____

Answer: reduced

Flashcard 298: Which drug of abuse increases binding of thyroid hormone to TBG?_____

Answer: Heroin

Flashcard 299: Which drug useful in gout increases the risk of MI and stroke?_____

Answer: Febuxostat

Flashcard 300: The most effective drug for the treatment of chemotherapy-induced and post-operative nausea and vomiting?

Answer: Palonosetron