Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 281: Which **amide** local anesthetic is considered the **least systemically toxic**?

Answer: Prilocaine

Extra: Prilocaine is considered the least systemically toxic **amide** local anesthetic because it is metabolized very rapidly (in both the liver and lungs). **Important Side Effect:** Its metabolite, *ortho-toluidine*, can cause **methemoglobinemia**, which is treated with intravenous methylene blue.

Flashcard 282: Which -vaptan is associated with dry mouth as an adverse effect?

Answer: Relcovaptan

Flashcard 283: _____ diluted with water is used to kill maggots in the nose

Answer: Chloroform

Flashcard 284: Is Naloxone useful in narcotic addicted mothers?_____

Answer: No

Flashcard 285: The most common cause of agranulocytosis is _____

Answer: drug toxicity

Flashcard 286: _____ is a highly selective NK1 receptor antagonist with an exceptionally long plasma half-life

Answer: Rolapitant

Flashcard 287: The most common hepatotoxin causing acute liver failure is _____

Answer: acetaminophen

Flashcard 288: Which drug used for lepra reaction is associated with "drug-induced lipofuscinosis"?_____

Answer: Clofazimine

Flashcard 289: Which teratogenic drug leads to cutis laxa syndrome?_____

Answer: Penicillamine

Flashcard 290: The maximum dose of lignocaine given with adrenaline for infiltration anesthesia should not exceed _____mg/kg

Answer: 7