Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 271: Adverse effects of Ezogabine include skin _____ and retinal damage

Answer: hyperpigmentation

Flashcard 272: What is the inhalational anesthetic of choice in patients with renal disease?_____

Answer: Desflurane

Flashcard 273: Cornea verticillate/vortex keratopathy is a whorl-like opacity in the corneal epithelium seen with _____

Answer: amiodarone (drug)

Flashcard 274: Which -vaptan is asssociated with hepatotoxicity as an adverse effect?_____

Answer: Tolvaptan

Flashcard 275: Which -vaptan is associated with dry mouth as an adverse effect?

Answer: Relcovaptan

Flashcard 276: _____ is considered the least toxic among other lead compounds

Answer: Lead sulphide

Flashcard 277: Which **amide** local anesthetic is considered the **least systemically toxic**?

Answer: Prilocaine

Extra: Prilocaine is considered the least systemically toxic **amide** local anesthetic because it is metabolized very rapidly (in both the liver and lungs). **Important Side Effect:** Its metabolite, *ortho-toluidine*, can cause **methemoglobinemia**, which is treated with intravenous methylene blue.

Flashcard 278: Which vitamin, when infused in supraphysiological doses, cause macular oedema and macular cysts? _____

Answer: Vitamin B3

Flashcard 279: Which SERM use is associated with cataracts?_____

Answer: Tamoxifen (SERM)

Flashcard 280: _____ toxicity causes secondary parkinsonism.

Answer: Manganese