Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 271: _____ is a 15-methyl synthetic derivative of PGF2 alpha used as an abortifacient and in refractory PPH

Answer: Carboprost

Flashcard 272: Cornea verticillate/vortex keratopathy is a whorl-like opacity in the corneal epithelium seen with _____

Answer: amiodarone (drug)

Flashcard 273: Which -vaptan is asssociated with injection site pain as an adverse effect?_____

Answer: Conivaptan

Flashcard 274: _____ is a plant extract that is commonly used for hyperlipidemia but has very little/no evidence to support its use

Answer: Gugulipid

Flashcard 275: Female patients should avoid getting pregnant for _____ after receiving acitretin treatment to prevent retinoid-induced embryopathy

Answer: 3 years

Flashcard 276: _____ is considered the least toxic among other lead compounds

Answer: Lead sulphide

Flashcard 277: Which -vaptan is asssociated with hepatotoxicity as an adverse effect?_____

Answer: Tolvaptan

Flashcard 278: Which vitamin, when infused in supraphysiological doses, cause macular oedema and macular cysts? _____

Answer: Vitamin B3

Flashcard 279: _____ toxicity causes secondary parkinsonism.

Answer: Manganese

Flashcard 280: Which **amide** local anesthetic is considered the **least systemically toxic**?

Answer: Prilocaine

Extra: Prilocaine is considered the least systemically toxic **amide** local anesthetic because it is metabolized very rapidly (in both the liver and lungs). **Important Side Effect:** Its metabolite, *ortho-toluidine*, can cause **methemoglobinemia**, which is treated with intravenous methylene blue.