Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 251: Which SERM is associated with a three-fold increased risk of deep vein thrombosis and pulmonary embolism?_____

Answer: Raloxifene

Flashcard 252: What is the cause of bronchospasm in opioid intoxication?_____

Answer: Histamine release

Flashcard 253: Absolute contraindications to combined oral contraceptive use: Congenital _____

Answer: hyperlipidemia

Flashcard 254: Succimer is used for severe _____ organic mercury poisoning

Answer: acute (acute/chronic)

Flashcard 255: Which teratogenic drug leads to autism spectrum disorder and coarctation of aorta?_____

Answer: Valproate

Flashcard 256: Propofol has anti_____ properties, which may be useful in cholestasis

Answer: pruritic

Flashcard 257: Does RBC cholinesterase levels in OP poisoning have any prognostic significance?_____

Answer: NO

Flashcard 258: Multidose activated charcoal is used for _____ of a toxin.

Answer: enhanced elimination (mechanism of action)

Flashcard 259: Category _____: Varying and/or contradictory human and animal data

Answer: B

Flashcard 260: Bisphosphonates are _____ (recommended/not recommended) to be administered with food.

Answer: not recommended (food impairs absorption)

Extra: Bisphosphonates should be taken on an empty stomach with a full glass of water. Food, especially those containing calcium/cations, significantly decreases their absorption. To minimize esophageal irritation (pill esophagitis), patients must remain upright for 30-60 minutes after ingestion.