Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 251: Major side effect associated with Edaravone is _____

Answer: hypersensitivity

Flashcard 252: Absolute contraindications to combined oral contraceptive use: Congenital _____

Answer: hyperlipidemia

Flashcard 253: _____ are preferred to treat seizures in isoniazid overdose

Answer: Benzodiazepines and Pyridoxine (Vitamin B6)

Flashcard 254: Multidose activated charcoal is used for _____ of a toxin.

Answer: enhanced elimination (mechanism of action)

Flashcard 255: Succimer is used for severe _____ organic mercury poisoning

Answer: acute (acute/chronic)

Flashcard 256: Does RBC cholinesterase levels in OP poisoning have any prognostic significance?_____

Answer: NO

Flashcard 257: Propofol has anti_____ properties, which may be useful in cholestasis

Answer: pruritic

Flashcard 258: Which teratogenic drug leads to autism spectrum disorder and coarctation of aorta?_____

Answer: Valproate

Flashcard 259: Bisphosphonates are _____ (recommended/not recommended) to be administered with food.

Answer: not recommended (food impairs absorption)

Extra: Bisphosphonates should be taken on an empty stomach with a full glass of water. Food, especially those containing calcium/cations, significantly decreases their absorption. To minimize esophageal irritation (pill esophagitis), patients must remain upright for 30-60 minutes after ingestion.

Flashcard 260: Category _____: Varying and/or contradictory human and animal data

Answer: B