Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 241: Propofol contains egg _____ and hence not necessarily contraindicated in patients with a history of egg allergy

Answer: lecithin

Flashcard 242: Does ageing occur in carbamate poisoning?_____

Answer: No

Flashcard 243: Which local anesthetic causes maximum methemoglobinemia?_____

Answer: Prilocaine

Flashcard 244: Hyponatremia risk with oxcarbazepine is _____ when compared to carbamazepine

Answer: higher (higher/lower)

Flashcard 245: Shellfish poisoning is due to the neurotoxin _____

Answer: Saxitoxin

Flashcard 246: What is the name of the severe allergic reaction caused by the rapid death of microfilariae following the administration of **Diethylcarbamazine (DEC)**?

Answer: Mazzotti reaction

Extra: The Mazzotti reaction is a severe systemic response observed following the administration of **Diethylcarbamazine (DEC)** for the treatment of microfilarial infections, most classically **Onchocerciasis**. It is caused by the release of antigens from the dying microfilariae, leading to symptoms such as fever, tachycardia, hypotension, and skin rash.

Flashcard 247: Major side effect associated with Edaravone is _____

Answer: hypersensitivity

Flashcard 248: Immunosuppressants for anterior uveitis are studied under a program called _____

Answer: LUMINATE

Flashcard 249: _____ are preferred to treat seizures in isoniazid overdose

Answer: Benzodiazepines and Pyridoxine (Vitamin B6)

Flashcard 250: Which SERM is associated with a three-fold increased risk of deep vein thrombosis and pulmonary embolism?_____

Answer: Raloxifene