Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 231: Which phase of clinical trials involves real world patients?_____

Answer: Phase IV

Flashcard 232: Do Carbamates cause Intermediate syndrome?

Answer: No

Extra: Intermediate syndrome is characteristically associated with **Organophosphate** poisoning (occurring 24-96 hours after exposure). It is generally **not** seen with carbamate poisoning because carbamates are reversible inhibitors of acetylcholinesterase and have a shorter duration of action.

Flashcard 233: _____ is associated with vestibular toxicity

Answer: Minocycline (Tetracycline)

Flashcard 234: Which antimalarial has a "black box" warning due to serious and permanent neuropsychiatric manifestations?_____

Answer: Mefloquine

Flashcard 235: A patient having a hypersensitivity reaction to phenytoin warrants _____

Answer: discontinuation of phenytoin

Flashcard 236: Isopropyl alcohol is _____ toxic than methyl alcohol

Answer: less

Flashcard 237: Which phase of drug development does not require Good Clinical Practice (GCP)?

Answer: Preclinical phase (requires Good Laboratory Practice [GLP])

Flashcard 238: Shellfish poisoning is due to the neurotoxin _____

Answer: Saxitoxin

Flashcard 239: Which IV anesthetic is associated with hypertriglyceridemia and hence pancreatitis?_____

Answer: Propofol

Flashcard 240: Does ageing occur in carbamate poisoning?_____

Answer: No