Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 151: _____ use/toxicity can cause ST depression ('scooped' appearance) and shortened QT interval; acute toxicity is associated with hyperkalemia.

Answer: Digoxin

Extra: Digoxin effect (therapeutic or chronic): 'Scooped' ST segment (Salvador Dali mustache), T-wave flattening/inversion, and shortened QT interval. Acute Digoxin toxicity: Hyperkalemia is a marker of severe toxicity and a predictor of mortality. Hyperkalemia itself causes peaked T waves.

Flashcard 152: A common adverse effect associated with niacin is cutaneous _____ and warmth due to increased prostaglandin activity

Answer: flushing

Flashcard 153: What is the treatment of Menke's disease?_____ and L-Histidine injections

Answer: Copper chloride

Flashcard 154: Amiodarone may act as a hapten resulting in _____ skin discoloration with photodermatitis

Answer: gray-blue

Flashcard 155: Glucocorticoids inhibit the proliferation of _____ thus impairing the process of wound healing

Answer: fibroblasts

Flashcard 156: Which antibiotics (2) can prolong the QT interval? _____

Answer: Macrolides and Fluoroquinolones

Flashcard 157: Can the MMR vaccine be given to pregnant patients? _____

Answer: No (it is a live, attenuated vaccine)

Flashcard 158: _____-ANCAs are induced by several therapeutic agents, particularly propylthiouracil.

Answer: MPO/p

Flashcard 159: Cholestatic DrugsPatients using Obeticholic Acid commonly experience _____, but incorrect dosing can lead to serious liver injury

Answer: itching

Flashcard 160: Drugs that cause acute _____ may be remembered with the 5 'P's' Pee (diuretics) Pain-free (NSAIDs) Penicillins (and cephalosporins) Proton pump inhibitors RifamPin

Answer: interstitial nephritis