Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 151: _____ use/toxicity can cause ST depression ('scooped' appearance) and shortened QT interval; acute toxicity is associated with hyperkalemia.

Answer: Digoxin

Extra: Digoxin effect (therapeutic or chronic): 'Scooped' ST segment (Salvador Dali mustache), T-wave flattening/inversion, and shortened QT interval. Acute Digoxin toxicity: Hyperkalemia is a marker of severe toxicity and a predictor of mortality. Hyperkalemia itself causes peaked T waves.

Flashcard 152: What is the treatment of Menke's disease?_____ and L-Histidine injections

Answer: Copper chloride

Flashcard 153: Use of Griseofulvin is contraindicated in _____ and/or breast-feeding women

Answer: pregnant

Flashcard 154: Amiodarone may act as a hapten resulting in _____ skin discoloration with photodermatitis

Answer: gray-blue

Flashcard 155: _____ deficiency causes increased risk of thrombotic skin necrosis with hemorrhage after warfarin administration

Answer: Protein C and S

Flashcard 156: _____-ANCAs are induced by several therapeutic agents, particularly propylthiouracil.

Answer: MPO/p

Flashcard 157: Which antibiotics (2) can prolong the QT interval? _____

Answer: Macrolides and Fluoroquinolones

Flashcard 158: Cholestatic DrugsPatients using Obeticholic Acid commonly experience _____, but incorrect dosing can lead to serious liver injury

Answer: itching

Flashcard 159: Cocaine can cause nasal mucosal _____ or septal perforation due to vasoconstriction

Answer: atrophy

Flashcard 160: Drugs that cause acute _____ may be remembered with the 5 'P's' Pee (diuretics) Pain-free (NSAIDs) Penicillins (and cephalosporins) Proton pump inhibitors RifamPin

Answer: interstitial nephritis