Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 141: _____ use is associated with dilutional hyponatremia.

Answer: Chlorpropamide

Flashcard 142: The inhaled anesthetic _____ is most commonly associated with hepatotoxicity as an adverse effect

Answer: halothane

Flashcard 143: First Aid Pharmacology: Neuro/Psych_____ is a local anesthetic that is associated with severe cardiovascular toxicity

Answer: Bupivacaine

Flashcard 144: Long term use of Linezolid can result in _____ and peripheral neuropathy

Answer: optic

Flashcard 145: Probenecid _____ uric acid excretion, thus increasing the risk of uric acid kidney stones

Answer: increases

Flashcard 146: Sevelamer is used to treat _____ due to chronic kidney disease.

Answer: hyperphosphatemia

Flashcard 147: Children with _____ encephalopathy should receive combined chelation therapy with Dimercaprol  and calcium disodium edetate (CaNa2EDTA).

Answer: lead

Flashcard 148: The inhaled anesthetic _____ can induce seizures and cause nephro-toxicity as adverse effects

Answer: enflurane

Flashcard 149: Amiodarone may act as a hapten resulting in _____ skin discoloration with photodermatitis

Answer: gray-blue

Flashcard 150: _____ use/toxicity can cause ST depression ('scooped' appearance) and shortened QT interval; acute toxicity is associated with hyperkalemia.

Answer: Digoxin

Extra: Digoxin effect (therapeutic or chronic): 'Scooped' ST segment (Salvador Dali mustache), T-wave flattening/inversion, and shortened QT interval. Acute Digoxin toxicity: Hyperkalemia is a marker of severe toxicity and a predictor of mortality. Hyperkalemia itself causes peaked T waves.