Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 141: The inhaled anesthetic _____ is most commonly associated with hepatotoxicity as an adverse effect

Answer: halothane

Flashcard 142: Long term use of Linezolid can result in _____ and peripheral neuropathy

Answer: optic

Flashcard 143: Probenecid _____ uric acid excretion, thus increasing the risk of uric acid kidney stones

Answer: increases

Flashcard 144: NNRTIs can cause _____ failure, with resulting jaundice cutaneously

Answer: liver

Flashcard 145: _____ damage symptoms predominate in ethylene glycol poisoning

Answer: Kidney

Flashcard 146: Sevelamer is used to treat _____ due to chronic kidney disease.

Answer: hyperphosphatemia

Flashcard 147: The inhaled anesthetic _____ can induce seizures and cause nephro-toxicity as adverse effects

Answer: enflurane

Flashcard 148: Use of Griseofulvin is contraindicated in _____ and/or breast-feeding women

Answer: pregnant

Flashcard 149: _____ use/toxicity can cause ST depression ('scooped' appearance) and shortened QT interval; acute toxicity is associated with hyperkalemia.

Answer: Digoxin

Extra: Digoxin effect (therapeutic or chronic): 'Scooped' ST segment (Salvador Dali mustache), T-wave flattening/inversion, and shortened QT interval. Acute Digoxin toxicity: Hyperkalemia is a marker of severe toxicity and a predictor of mortality. Hyperkalemia itself causes peaked T waves.

Flashcard 150: The H2 receptor antagonist _____ has many anti-androgenic effects (e.g. gynecomastia, impotence, elevated prolactin levels)

Answer: cimetidine