Antimicrobial Agents — Flashcards

Flashcard 381: Nitazoxanide acts by inhibiting _____ enzyme

Answer: PFOR

Flashcard 382: The antitubercular drug that is implicated in the causation of transient memory loss is _____.

Answer: Isoniazid

Flashcard 383: Which drug is used for the treatment of pregnant women with giardiasis?_____

Answer: Paromomycin

Flashcard 384: VZV vaccine is based on the _____ strain

Answer: OKA

Flashcard 385: Which antifungals are associated with exacerbation of psoriasis?_____

Answer: Terbinafine

Flashcard 386: Which drug can lead to formation of noncaseating epithelioid granulomas in the liver?_____

Answer: Isoniazid

Extra: Tuberculosis (the disease) is characterized by **caseating** granulomas. In contrast, Isoniazid (the drug) can cause **noncaseating** epithelioid granulomas in the liver as part of a drug-induced granulomatous hepatitis. **Important Distinctions:** - **Granulomatous Hepatitis (Liver):** Isoniazid, Sulfonamides, Allopurinol, Quinidine, Phenytoin, Methyldopa. - **Sarcoid-like Reaction (Systemic):** Interferon-alpha, Ipilimumab, TNF-alpha inhibitors. - **Berylliosis:** Chronic exposure to Beryllium.

Flashcard 387: The neuraminidase inhibitor available for intravenous administration for acute influenza is _____.

Answer: peramivir

Flashcard 388: Which antifungal is occasionally used in the treatment of visceral and dermal leishmaniasis?_____

Answer: Ketoconazole

Flashcard 389: Griseofulvin is an __________ acting carcinogen.

Answer: Indirectly

Flashcard 390: Which antibiotics exhibit concentration dependent killing?_____

Answer: Aminoglycosides