Quinolones — Flashcards

Flashcard 1: Which fluoroquinolone is NOT approved for use in UTIs?_____

Answer: Moxifloxacin

Flashcard 2: Which fluoroquinolones have the maximum bioavailability?_____

Answer: Levofloxacin and ofloxacin

Flashcard 3: The fluoroquinolones _____ and moxifloxacin can be used to treat Streptococcus pneumoniae, Haemophilus spp. (community-acquired pneumonia)

Answer: levofloxacin

Flashcard 4: Penicillins inhibit the ability of bacteria to generate a cell wall, which causes death by _____. In addition, penicillins allow accumulation of peptidoglycan precursors, which activates bacterial autolysis.

Answer: osmolysis

Flashcard 5: Which fluoroquinolone has clinically significant activity against anaerobes such as B. fragilis?_____

Answer: Moxifloxacin

Flashcard 6: Which fluoroquinolone has high activity against M. leprae?_____

Answer: Ofloxacin

Flashcard 7: Which **fluoroquinolone** has the highest risk for QT interval prolongation and torsades de pointes?

Answer: Moxifloxacin

Flashcard 8: Fluoroquinolones inhibit _____ and Topoisomerase IV.

Answer: DNA gyrase (Topoisomerase II)

Extra: In Gram-negative bacteria, DNA gyrase is the primary target. In Gram-positive bacteria, topoisomerase IV is the primary target.

Flashcard 9: Which step ([A] - [E]) of Bacterial Protein Synthesis do Aminoglycosides inhibit? _____

Answer: [B]

Flashcard 10: Which step ([A] - [E]) of Bacterial Protein Synthesis does Clindamycin inhibit? _____

Answer: [D]