Antimicrobial Agents — Flashcards

Flashcard 231: Macrolides (azithromycin) treat _____ caused by Legionella, Chlamydia, and Mycoplasma pneumoniae.

Answer: atypical "walking" pneumonia

Flashcard 232: Quinolines block the detoxification of _____ into hemozoin by Plasmodium spp.

Answer: heme

Flashcard 233: _____ is a nucleotide analog that inhibits the HCV NS5B RNA-dependent RNA polymerase

Answer: Sofosbuvir

Flashcard 234: _____ is a GABA receptor agonist, and causes flaccid paralysis of Ascaris

Answer: Piperazine

Flashcard 235: Loa loa is treated with _____ or albendazole

Answer: diethylcarbamazine

Flashcard 236: Which two antibiotics are used to treat nosocomial MRSA infections? _____ and _____

Answer: Vancomycin

Flashcard 237: Sulfamethoxazole (SMX) is a _____ analog, thus inhibiting the enzyme dihydropteroate synthase

Answer: PABA

Flashcard 238: What drugs (2) are used to prevent breakouts of Herpes Simplex Virus? _____

Answer: Acyclovir and Valacyclovir

Extra: Acyclovir, Valacyclovir, and Famciclovir can be used for chronic suppressive therapy to reduce the frequency of genital herpes recurrences by 70%–80%. Valacyclovir and Famciclovir have better bioavailability and require less frequent dosing than Acyclovir.

Flashcard 239: Treatment of the _____ form of Leprosy includes Rifampin, Dapsone and Clofazimine for 6 months (time)

Answer: Tuberculoid

Flashcard 240: The primary mode of resistance to fluoroquinolones is due to mutation in _____ or due to plasmid-mediated resistance

Answer: DNA gyrase