Antimicrobial Agents — Flashcards

Cephalosporins (and other _____ antibiotics) mimic the D-ala-D-ala sequence of peptidoglycans, binding irreversibly to penicillin binding protein transpeptidases

Which azoles (2) can treat candidal esophagitis in AIDS patients? _____, Voriconazole

Which two antibiotics are commonly used to treat vancomycin-resistant bacteria (e.g., VRE, VRSA)? _____ and Daptomycin

Lack of thymidine-kinase to phosphorylate acyclovir explains why the drug is not effective in _____ and EBV

Azoles inhibit the conversion of _____ to ergosterol

_____ include cefepime

_____ are anti-bacterials that have bulky R-groups that block access to the beta-lactam ring, making them penicillinase/beta-lactamase resistant.

Specific indications for _____ include **RACE**: - **R**: Refractory aspergillosis - **A**: Azole-resistant Candida - **C**: Candidemia - **E**: Empiric treatment in a febrile, neutropenic patient

Recurrence of genital HSV can be suppressed or minimized with a _____ administration of valacyclovir

The allylamine _____ is associated with hepato-toxicity