Antimicrobial Agents — Flashcards

_____ is used to treat staph epidermidis, which creates a biofilm on prosthetic devices

Mechanism of resistance of linezolid includes a _____ mutation of the ribosomal RNA

Cephalosporins that do not require dose reduction in a patient with renal failure is _____ and cefpiramide

Amphotericin B or _____ (drug class) can be used for systemic candidal infections

_____ is used to treat anaerobic infections above the diaphragm

_____ and Velpatasvir has now been approved as the first-line treatment of hepatitis C genotypes 1-6

Hint: NS5B polymerase inhibitor

Chloramphenicol is used to treat _____ caused by Strep pneumoniae, H. influenzae and Neisseria meningitidis

Aminopenicillins (amoxicillin and ampicillin) can treat pneumonia caused by _____ and H. influenzae.

_____ mutation (associated with the use of lamivudine or emtricitabine) restores zidovudine susceptibility in zidovudine-resistant HIV.

To remember the protein synthesis inhibiting antibiotics, the mnemonic "Buy AT 30, CCEL at 50" is used. **30S inhibitors:** _____ Tetracyclines (block aminoacyl-tRNA binding) **50S inhibitors:** Chloramphenicol (inhibits peptidyltransferase) Clindamycin (inhibits translocation) Erythromycin / Macrolides (inhibits translocation) Linezolid (prevents initiation complex formation)