Neoplasia — Flashcards

2-Napthylamine is a carcinogenic aromatic amine found in _____ associated with Transitional Cell Carcinoma of the Bladder

Wilms tumor is caused by "loss of function" mutations of tumor suppression genes _____ or WT2 on chromosome 11

_____ is a malignant salivary gland tumor composed of mucinous and squamous cells *what is the most common mutation?

ER/PR-_____, HER2-negative cancers is the most common subtype of breast cancer in individuals who inherit germline mutations in BRCA1

_____ is a salivary gland tumor composed of chondromyxoid stroma and epithelium

-fetoprotein (AFP) is a serum tumor marker elevated in (mnemonic: HE-MAN is the alpha male)- H_____- Endodermal sinus (yolk sac) tumor- Mixed germ cell tumor- Ataxia-telangiectasia- Neural tube defects

A follicular lymphoma due to Bcl-2 overexpression results from a _____ mutation

Her2 enriched subtype of breast cancer usually has a _____ Ki67

Peutz-Jeghers-Touraine syndrome is due to loss-of-function mutation of _____ gene

IHC score is said to be 1+ if the breast cancer is HER2 _____