Hematopathology — Flashcards

Flashcard 311: What AML subtype is associated with chloromas?_____

Answer: AML M2, M5a, M5b, M4

Flashcard 312: _____ disease is sinus histiocytosis with massive lymphadenopathy

Answer: Rosai Dorfman

Flashcard 313: Are Bence Jones proteins seen in urine in monoclonal gammopathy of undetermined significance (MGUS)?

Answer: No (or characteristically absent)

Extra: MGUS is defined by: 1. Serum M-protein < 3 g/dL 2. Bone marrow plasma cells < 10% 3. No CRAB symptoms (end-organ damage) 4. **No significant Bence Jones proteinuria** (< 500 mg/24h) Bence Jones proteins (monoclonal free light chains) in the urine are a hallmark of Multiple Myeloma.

Flashcard 314: The most common cytogenetic abnormality associated with lymphoplasmacytic lymphoma is deletion of _____

Answer: 6q

Flashcard 315: von Willebrand disease associated with thrombocytopenia is Type 2_____.

Answer: B

Flashcard 316: What is the inheritence pattern of Glanzmann thrombasthenia?_____

Answer: Autosomal Recessive

Flashcard 317: The most common chromosomal defect seen in Chronic lymphocytic leukemia is the deletion of _____

Answer: 13q

Flashcard 318: Is hemophagocytosis on bone marrow examination sufficient to make the diagnosis of hemophagocytic lymphohistiocytosis?_____

Answer: No

Flashcard 319: _____ is the most specific and sensitive marker for Hairy-cell leukemia

Answer: Annexin A1

Flashcard 320: The lower blasts cutoff percentage for diagnosing acute lymphoblastic leukemia (ALL) on bone marrow biopsy is _____%.

Answer: 20% (WHO criteria)