Hematopathology — Flashcards

Flashcard 311: What is the inheritence pattern of Glanzmann thrombasthenia?_____

Answer: Autosomal Recessive

Flashcard 312: A patient of PNH will show _____ MCV due to increased reticulocytosis

Answer: high

Flashcard 313: Are Bence Jones proteins seen in urine in monoclonal gammopathy of undetermined significance (MGUS)?

Answer: No (or characteristically absent)

Extra: MGUS is defined by: 1. Serum M-protein < 3 g/dL 2. Bone marrow plasma cells < 10% 3. No CRAB symptoms (end-organ damage) 4. **No significant Bence Jones proteinuria** (< 500 mg/24h) Bence Jones proteins (monoclonal free light chains) in the urine are a hallmark of Multiple Myeloma.

Flashcard 314: The most common cytogenetic abnormality associated with lymphoplasmacytic lymphoma is deletion of _____

Answer: 6q

Flashcard 315: von Willebrand disease associated with thrombocytopenia is Type 2_____.

Answer: B

Flashcard 316: Is hemophagocytosis on bone marrow examination sufficient to make the diagnosis of hemophagocytic lymphohistiocytosis?_____

Answer: No

Flashcard 317: Which AML subtype is negative for myeloperoxidase?_____

Answer: AML M0, M5, M6 and M7

Flashcard 318: Which immunohistochemical marker is associated with cyclin D1 negative mantle cell lymphoma?_____

Answer: SOX11

Flashcard 319: Increased MCHC in hereditary spherocytosis is due to _____ caused by the loss of K+ and H2O.

Answer: dehydration

Flashcard 320: _____ is the most specific and sensitive marker for Hairy-cell leukemia

Answer: Annexin A1