Hematopathology — Flashcards

Flashcard 311: von Willebrand disease associated with thrombocytopenia is Type 2_____.

Answer: B

Flashcard 312: What is the inheritence pattern of Glanzmann thrombasthenia?_____

Answer: Autosomal Recessive

Flashcard 313: Are Bence Jones proteins seen in urine in monoclonal gammopathy of undetermined significance (MGUS)?

Answer: No (or characteristically absent)

Extra: MGUS is defined by: 1. Serum M-protein < 3 g/dL 2. Bone marrow plasma cells < 10% 3. No CRAB symptoms (end-organ damage) 4. **No significant Bence Jones proteinuria** (< 500 mg/24h) Bence Jones proteins (monoclonal free light chains) in the urine are a hallmark of Multiple Myeloma.

Flashcard 314: A patient of PNH will show _____ MCV due to increased reticulocytosis

Answer: high

Flashcard 315: _____ disease is sinus histiocytosis with massive lymphadenopathy

Answer: Rosai Dorfman

Flashcard 316: Increased MCHC in hereditary spherocytosis is due to _____ caused by the loss of K+ and H2O.

Answer: dehydration

Flashcard 317: The lower blasts cutoff percentage for diagnosing acute lymphoblastic leukemia (ALL) on bone marrow biopsy is _____%.

Answer: 20% (WHO criteria)

Flashcard 318: Is Ph chromosome seen in JMML?_____

Answer: No

Flashcard 319: Which immunohistochemical marker is associated with cyclin D1 negative mantle cell lymphoma?_____

Answer: SOX11

Flashcard 320: Is hemophagocytosis on bone marrow examination sufficient to make the diagnosis of hemophagocytic lymphohistiocytosis?_____

Answer: No