Hematopathology — Flashcards

Flashcard 191: G6PD deficiency presents with _____-uria and back pain hours after exposure to oxidative stress

Answer: hemoglobin

Flashcard 192: Diagnosis of _____ is confirmed by an isolated increase in HbA2 (> 3.5%) on electrophoresis

Answer: β-thalassemia minor

Flashcard 193: Primary effusion lymphoma is also known as _____ lymphoma and is a B-cell lymphoma

Answer: body cavity based

Flashcard 194: The cells in _____ leukemia stain positive for tartrate-resistant acid phosphatase (TRAP)

Answer: hairy cell

Flashcard 195: During sleep, mild respiratory _____ develops due to shallow breathing causing activation of complement, which may then trigger PNH

Answer: acidosis

Flashcard 196: Risk factors for acute myeloid leukemia include prior exposure to _____ chemotherapy and radiation

Answer: alkylating

Flashcard 197: _____ is an anemia due to defective protoporphyrin synthesis

Answer: Sideroblastic anemia

Flashcard 198: The _____ screen causes cells with any amount of HbS to sickle

Answer: metabisulfite

Flashcard 199: Shift of the osmotic fragility curve to the _____ indicates hereditary spherocytosis

Answer: right

Flashcard 200: Marginal zone lymphoma (MALT type) can harbour _____, t(1;14), or t(14;18) translocations that render their growth and survival antigen-independent.

Answer: t(11;18)

Extra: These translocations lead to constitutive activation of the **NF-κB** pathway, bypassing the need for chronic antigen stimulation (e.g., *H. pylori*): - **t(11;18)(q21;q21)**: *BIRC3-MALT1* (formerly *API2-MALT1*) — most common. - **t(1;14)(p22;q32)**: *BCL10-IGH*. - **t(14;18)(q32;q21)**: *IGH-MALT1* (Distinct from the t(14;18) in follicular lymphoma which involves *BCL2*).