Hematopathology — Flashcards

Flashcard 171: In paroxysmal cold hemoglobinuria, Ig_____ antibodies (Donath Landsteiner abx) are directed against the P blood group antigen.

Answer: G

Flashcard 172: Vitamin K deficiency presents with _____ PT and increased (in severe cases) PTT

Answer: increased

Flashcard 173: Hodgkin's lymphoma often presents as a _____ mass or nontender lymphadenopathy

Answer: mediastinal

Extra: Nodular Sclerosis is the most common subtype of Hodgkin Lymphoma and typically presents with a mediastinal mass (often in young adult females). Mixed Cellularity is the subtype most strongly associated with EBV (~70% of cases) and usually presents with peripheral lymphadenopathy and B-symptoms.

Flashcard 174: _____ or t(9;22) is a poor prognostic marker for ALL.

Answer: Pseudodiploidy

Flashcard 175: _____ - ALL usually presents in teenagers (age group) as a mediastinal mass, thus it is often referred to as acute lymphoblastic lymphoma

Answer: T

Flashcard 176: Normal platelet count is between _____ and 400,000/µL

Answer: 150,000

Flashcard 177: Diagnosis of _____ is confirmed by an isolated increase in HbA2 (> 3.5%) on electrophoresis

Answer: β-thalassemia minor

Flashcard 178: Glanzmann thrombasthenia shows decreased levels on CD_____ and CD61 on flow cytometry

Answer: 41

Flashcard 179: Ig_____-mediated immune hemolytic anemia usually causes intravascular hemolysis

Answer: M

Flashcard 180: The blasts seen in acute leukemia are _____ (size), immature cells, often with 'punched out' nucleoli

Answer: large