Hematopathology — Flashcards

Flashcard 101: α-thalassemia due to a _____ gene deletion is characterized by formation of β4 tetramers, known as HbH

Answer: three

Flashcard 102: Megaloblastic anemia occurs due to delayed maturation of the _____ relative to the cytoplasm of precursor RBCs

Answer: nucleus

Flashcard 103: β-thalassemia mutations in β-globin genes result in _____ or diminished (β+) production of the β-globin chain

Answer: absent (β0)

Flashcard 104: A normal reticulocyte count is between _____ to 1.5%

Answer: 0.5

Flashcard 105: The typical normal values for a WBC differential (per USMLE) are:Neutrophils (~ _____%)Lymphocytes (~ 30%)Monocytes (~ 6%)Eosinophils (~ 3%)Basophils (~ 1%)

Answer: 60

Flashcard 106: _____ is important and the strongest predictor of prognosis for Hodgkin lymphoma (Hodgkin or non-Hodgkin)

Answer: Staging

Flashcard 107: Lymphomas are malignancies of _____ leukocytes, whereas Leukemias are malignancies of immature leukocytes

Answer: mature

Flashcard 108: Diagnostic criteria for CMML includes persistent peripheral blood monocytosis ≥ _____ x 10⁹/L, with monocytes accounting for ≥ 10% of the WBC count.

Answer: 1

Extra: WHO Diagnostic Criteria for CMML: 1. Persistent peripheral blood monocytosis ≥ 1 x 10⁹/L. 2. Monocytes account for ≥ 10% of the WBC count. 3. Blast count in blood and bone marrow is < 20%. 4. Not meeting WHO criteria for BCR-ABL1+ CML, PV, ET, or PMF. 5. No rearrangement of PDGFRA, PDGFRB, FGFR1, or PCM1-JAK2.

Flashcard 109: _____ is an anemia due to decreased synthesis of globin chains

Answer: Thalassemia

Flashcard 110: The _____ Coombs test adds anti-human globulin (Coombs reagent) to a sample of a patient's RBCs

Answer: direct