Dermatopathology — Flashcards

What is the MOA of exfoliative toxin in Scalded-Skin Syndrome? Destroys _____ attachments in statum granulosum, causing skin to slough off

Langerhans cells are positive for _____ and S100 on immunohistochemistry

Extramammary paget disease of the vulva may be distinguished from melanoma by the following immunohistological features: 1. PAS _____ 2. Keratin + 3. S100 -

In regards to wrinkles of aging, there is _____ synthesis of collagen fibrils and increased crosslinking of collagen

Homogeneous, _____philic, rounded body resulting from degeneration and death of keratinocytes, is known as Civatte body

Cylindroma is due to mutation of _____ gene on chromosome 16q12-13

Langerhans cells have a single large nucleus with a characteristic folded or grooved nucleus ( _____ appearance) with small inconspicuous nucleoli and an eosinophilic cytoplasm

_____ leprosy presents as a spindle-cell proliferation with storiform pattern

Grenz zone is absent in _____ leprosy because the dermal tuberculoid granulomas extend upto the epidermis, thus obstructing the Grenz zone

Papillary _____ is a disorder of anogenital mammary-like apocrine glands, which presents as a benign nodule on the labia majora or interlabial folds, and may ulcerate