Immunology — Flashcards

Flashcard 61: MHC _____ presents endogenously synthesized antigens to CD8+ cytotoxic T cells

Answer: I

Flashcard 62: _____zone phenomenon has excessive antibody in the test system, leading to weak or even absent precipitation.

Answer: Pro

Flashcard 63: Antigen-independent antibody diversity in _____ chains is generated by V(D)J gene recombination

Answer: heavy

Flashcard 64: _____ binds factor H and breaks down C3-convertase

Answer: M protein

Flashcard 65: _____ and Interferon-β are glycoproteins synthesized by virus-infected cells that act locally on uninfected cells, "priming" them for viral defense

Answer: Interferon-α

Extra: Type I Interferons (IFN-α and IFN-β) act in a paracrine fashion to induce an antiviral state in neighboring cells by activating RNAse L (degrades viral mRNA) and Protein Kinase R (inhibits translation initiation).

Flashcard 66: Antigen loading onto MHC I occurs in the RER after breakdown of endogenous antigen by the _____ in the cytosol, and delivery to the RER via TAP (transporter associated with antigen processing)

Answer: proteasome

Flashcard 67: MHC _____ binds to the T-cell receptor (TCR) and CD-4

Answer: II

Flashcard 68: Interferon-_____ is produced by leukocyte

Answer: alpha

Flashcard 69: V(D)J recombination in heavy chains begins with _____ joining, followed by V-D/J joining

Answer: D-J

Flashcard 70: Endotoxin/Lipopolysaccharide of Gram Negative Bacteria can activate the _____ system, resulting in release of C3a and C5a

Answer: complement