Autoimmunity and Autoimmune Diseases — Flashcards

Flashcard 1: An immune ring (Wesseley) may be seen around the fungal  ulcer due to deposition of the _____

Answer: immune complexes

Flashcard 2: _____ are antigens that cross-link the Vβ region of T-cell receptors to MHC II on APCs outside the normal peptide-binding groove

Answer: Superantigens

Flashcard 3: TSST-1 is a superantigen that binds to the _____ region on the T-cell receptor (TCR).

Answer: variable beta (Vβ)

Flashcard 4: _____ fully attach to an antigen present cell's (APC) MHC II and a T-cell's TCR, stimulating a large T-cell response

Answer: Superantigens

Flashcard 5: Bare lymphocyte disease occurs due to mutations in transcription factors required for class _____ MHC gene expression.

Answer: II

Flashcard 6: The part of the antigen associated with MHC molecule on the antigen-presenting cell is called as _____

Answer: aggretope

Flashcard 7: Which antibodies serve as recognition receptors for antigens on naive B cells?

Answer: IgM and IgD

Extra: Surface IgM and IgD serve as the B-cell receptors (BCR) on naive B cells for antigen recognition.

Flashcard 8: Which is the only heat labile antibody?_____

Answer: IgE

Flashcard 9: father of immunology is

Answer: Edward Jenner louis pasteur is the father of bacteriology

Extra: 

Flashcard 10: The enzymes responsible for gene recombination in heavy and light chains are encoded by the genes _____ and RAG2

Answer: RAG1