Immunology — Flashcards

Flashcard 41: The signal transduction region of B lymphocytes includes a heterodimer of _____ and Ig-beta

Answer: Ig-alpha

Extra: The Ig-alpha and Ig-beta heterodimer (also known as CD79a and CD79b) contains ITAMs (Immunoreceptor Tyrosine-based Activation Motifs) required for signal transduction when the B-cell receptor binds an antigen.

Flashcard 42: Antigen loading onto MHC II occurs following release of the _____ in an acidified endosome

Answer: invariant chain

Flashcard 43: The _____ test is an in-vivo neutralization test used to assess immunity against diphtheria.

Answer: Schick

Flashcard 44: _____ is a protein found in secretory fluids and neutrophils that inhibits microbial growth via iron chelation

Answer: Lactoferrin

Flashcard 45: Different types of immunodiffusions:_____ diffusion in two dimension - Ouchterlony procedure

Answer: Double

Flashcard 46: Differentiation of helper T cells to _____ is induced by IL-2 and IL-4

Answer: Th2

Flashcard 47: The first signal for T-cell activation is binding between the _____ and MHC/peptide complex

Answer: TCR

Flashcard 48: _____ on cells of the immune system are activated by pathogen-associated molecular patterns (PAMPs) that are commonly shared by microbes

Answer: Toll-like receptors (TLRs)

Flashcard 49: IL-12 stimulates polarization of naive TH0 cells towards a TH_____ phenotype and away from a TH2 phenotype

Answer: 1

Flashcard 50: Different types of immunodiffusions:_____ diffusion in one dimension - Oudin procedure

Answer: Single