Immunology — Flashcards

Mast cells can bind the _____ portion of IgE

Differentiation of helper T cells to _____ is induced by TGF-β and IL-2; inhibited by IL-6

Antibody _____ occurs via somatic hypermutation (point mutations in variable region genes).

The enzymes responsible for gene recombination in heavy and light chains are encoded by the genes _____ and RAG2

T cell _____ antigens activate only mature B cells, monoclonally

Type 1 T-cell _____ antigens activate immature and mature B cells polyclonally

Isotype switching is induced by cytokines, including _____ and IL-4.

Ig_____ exists as a pentamer held by a J chain when secreted

Each B-cell expresses a light chain that is either a _____ or lambda isoform

Complement may be activated via the _____ pathway, which is mediated by mannose on microbial surfaces