Hemoglobin and Iron Metabolism — Flashcards

In the first step of heme synthesis, _____ and succinyl-CoA are combined to form delta-aminolevulinic acid via the enzyme delta-aminolevulinic acid synthase (with vitamin B6 as a cofactor)

Delta-aminolevulinic acid synthase is regulated via negative feedback by _____ and heme

Gower-II has two _____ and two epsilon () chains

Heme is composed of _____ and protoporphyrin

The catabolism of heme from all heme proteins is carried out in the _____ fraction of cells by heme oxygenase.

Gower-I has two _____ and two epsilon () chains

Hb _____ results from globin chain mutations that stabilize iron in the ferric state, leading to congenital methemoglobinemia.

Disorders of fibrinolysis are due to _____ overactivity, resulting in excessive cleavage of serum fibrinogen

The Vitamin K-dependent clotting factor with the shortest half-life is Factor _____, whereas the one with the longest half-life is Factor II (prothrombin)

Methemoglobin has an _____ affinity for cyanide relative to hemoglobin