Hemoglobin and Iron Metabolism — Flashcards

_____ iron (vegetable-derived) must be converted to Fe2+ in the duodenum / proximal jejunum by cytochrome B and/or Vitamin C for absorption

Uroporphyrinogen III is converted to _____ via the enzyme uroporphyrinogen decarboxylase (heme synthesis)

δ-aminolevulinic acid is converted to _____ via the enzyme δ-aminolevulinic acid dehydratase (heme synthesis)

The _____ form of hemoglobin has a high affinity for O2

The two embryonic globins are _____ and epsilon (ε)

Delta-aminolevulinic acid synthase is regulated via negative feedback by _____ and heme

_____ and Fe2+ combine to form heme via the enzyme ferrochelatase

_____ iron (meat-derived) is readily absorbed and enters the duodenal cell via the heme transporter

Primary _____ is due to mutations in the HFE gene on chromosome 6, leading to increased expression of DMT1 and decreased synthesis of Hepcidin

_____ is a measure of transferrin molecules in the blood