Hemoglobin and Iron Metabolism — Flashcards

_____, probably acting through an aporepressor molecule, acts as a negative regulator of the synthesis of ALA Synthase-1 in the hepatic biosynthesis of Heme

In _____ porphyria, the teeth have a reddish discoloration, due to accumulation of Uroporphyrin I or Coproporphyrin I

In splenic macrophages, heme is metabolized to _____ by the enzyme heme oxygenase

Delta-aminolevulinic acid synthase is regulated via negative feedback by _____ and heme

The two embryonic globins are _____ and epsilon (ε)

_____ is a measure of transferrin molecules in the blood

_____ iron (meat-derived) is readily absorbed and enters the duodenal cell via the heme transporter

Primary _____ is due to mutations in the HFE gene on chromosome 6, leading to increased expression of DMT1 and decreased synthesis of Hepcidin

The _____ form of hemoglobin has a high affinity for O2

_____ and Fe2+ combine to form heme via the enzyme ferrochelatase