Biochemistry of Hemostasis — Flashcards

Flashcard 1: Primary _____ is due to mutations in the HFE gene on chromosome 6, leading to increased expression of DMT1 and decreased synthesis of Hepcidin

Answer: hemochromatosis

Flashcard 2: _____ is a measure of transferrin molecules in the blood

Answer: Total iron-binding capacity (TIBC)

Flashcard 3: _____ binds with heme, particularly for heme recycling.

Answer: Hemopexin

Flashcard 4: Endothelial cells prevent thrombosis by secreting _____ molecules, which augment antithrombin III (ATIII)

Answer: heparin-like

Flashcard 5: Disorders of fibrinolysis are due to _____ overactivity, resulting in excessive cleavage of serum fibrinogen

Answer: plasmin

Flashcard 6: One normal type of hemoglobin is _____ which is composed of two alpha and two gamma chains

Answer: HbF

Flashcard 7: Which 3 hemoglobins are also known as embryonic hemoglobins?_____

Answer: Gower-I, Gower-II, and Hb Portland

Flashcard 8: $\alpha$-thalassemia due to a _____ gene deletion is characterized by formation of \gamma_4 tetramers, known as Hb Barts

Answer: four

Extra: In $\alpha$-thalassemia with a 4-gene deletion (Hydrops fetalis), no $\alpha$-globin chains are produced. In the fetus, excess $\gamma$-chains form tetramers ($\gamma_4$), known as Hb Barts. These have such a high oxygen affinity that they do not release oxygen to tissues.

Flashcard 9: _____ is the most commonly used indicator for iron in low anemic areas

Answer: serum ferritin

Extra: 

Flashcard 10: Iron absorption inhibitors include: _____

Answer: phytates, oxalates, calcium, tannins